多次吡喹酮治疗抗血吸虫病肝纤维化疗效观察

发布时间：2018-02-23 07:21

  本文关键词： 血吸虫病 吡喹酮 纤维化　出处：《中国血吸虫病防治杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的观察多次吡喹酮治疗对抗血吸虫病肝纤维化的作用。方法选择60例血吸虫病肝纤维化患者(临床诊断病例),随机分成治疗组和对照组,每组30人。治疗组在常规护肝、对症治疗的基础上连续3年每年给予吡喹酮60 mg/kg,分2 d服完;对照组予以常规的护肝、对症治疗,2组疗程均为36个月。观察治疗前后2组患者临床症状、肝功能及血清透明质酸(HA)、层粘蛋白(LN)、4型胶原(IV-C)、Ⅲ型前胶原肽(PCIII)等肝纤维化指标的变化,并作统计分析。结果治疗组患者临床症状、肝功能及HA、LN、IV-C、PCIII水平均有不同程度下降,总有效率93%(26/28),对照组总有效率60%(16/27),两组差异有统计学意义(P0.05)。结论多次吡喹酮治疗对抗血吸虫病肝纤维化有较好的治疗效果。
[Abstract]:Objective to observe the protective effect of praziquantel on hepatic fibrosis of schistosomiasis. Methods 60 patients with hepatic fibrosis of schistosomiasis were randomly divided into treatment group (n = 30) and control group (n = 30). On the basis of symptomatic treatment, 60 mg / kg praziquantel was administered every year for 3 consecutive years, and the control group was given routine liver protection and the course of treatment was 36 months. The clinical symptoms of the two groups were observed before and after treatment. The changes of liver function and serum hyaluronic acid HAI, laminin LNN 4 collagen type IV-CN, type 鈪，

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