早期HIV相关神经认知紊乱的磁共振波谱研究

发布时间：2018-02-23 12:20

本文关键词： HIV 认知障碍磁共振成像磁共振波谱学　出处：《中国医学影像学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的探讨早期人类免疫缺陷病毒(HIV)相关神经认知紊乱(HAND)的磁共振波谱(MRS)改变以及MRS对早期HAND临床分期的价值。资料与方法采用二维多体素点分辨波谱对26例HAND 0.5期患者(A组)、18例HAND 0期患者(B组)及18例健康对照者(C组)进行扫描。对称测量双侧额叶白质及豆状核N-乙酰天门冬氨酸(NAA)、NAA/肌酸(Cr)、胆碱(Cho)值,比较组间各指标的差异。结果与C组相比,B组左侧额叶白质、左侧豆状核NAA值降低,差异有统计学意义(P0.05);A组双额叶白质和双侧豆状核NAA值以及双额叶白质NAA/Cr均降低,差异有统计学意义(P0.05)。与B组相比,A组仅右额叶白质区NAA值降低,差异有统计学意义(P0.05)。与C组和B组比较,A组右侧豆状核Cho值均减低,差异有统计学意义(P0.05)。结论 0期HAND患者MRS改变为左侧额叶白质及左侧豆状核NAA降低。右侧额叶白质NAA降低对HAND 0期及0.5期具有一定的参考价值,Cho改变在每个感兴趣区的变化不一致,在早期诊断及分期中的意义有待进一步研究。
[Abstract]:Objective to investigate the changes of magnetic resonance spectroscopy (MRS) and the value of MRS in clinical staging of early human immunodeficiency virus (HIV) related neurocognitive disorder (hand). Materials and methods two dimensional multivoxel point resolution spectroscopy was used to evaluate the clinical staging of HAND 0.5 in 26 cases of HAND. Group A (n = 18) and group B (n = 18) and group C (n = 18) were scanned. The values of N-acetylaspartate in bilateral frontal white matter and lentiform nucleus were measured symmetrically. Results compared with group C, the NAA values of left frontal lobe white matter and left lentiform nucleus in group B were significantly lower than those in group C. The difference was statistically significant (P 0.05). The NAA values of white matter and bilateral lentiform nucleus and NAA/Cr of double frontal lobe in group A were significantly lower than those in group C. The difference was statistically significant (P 0.05). Compared with group B, the NAA value of right frontal white matter area in group A was decreased, and the difference was statistically significant (P 0.05). Compared with group C and group B, the Cho value of right lentiform nucleus in group A was lower than that in group A. Conclusion the changes of MRS in the white matter of left frontal lobe and the left lentiform nucleus in patients with HAND in stage 0 are decreased. The decrease of NAA in white matter of right frontal lobe is of certain reference value in HAND stage 0 and 0. 5. The changes in the interesting area are not consistent, The significance of early diagnosis and staging needs further study.
【作者单位】：中南大学湘雅二医院放射科;长沙市第一医院放射科;
【基金】：湖南省卫生厅科研基金(B2014-146)
【分类号】：R445.2;R512.91

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