慢性丙型肝炎感染患者多项生化指标动态监测研究

发布时间：2018-02-24 11:00

本文关键词： 慢性丙型肝炎感染生化指标动态监测　出处：《中华医院感染学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的探讨慢性丙型肝炎感染患者多项生化指标动态监测特性。方法选择2012年12月-2014年12月医院收治的慢性丙型肝炎感染患者80例,根据患者慢性丙型肝炎感染中血清病毒载量的多少,分为高复制组36例和低复制组44例,对两组的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、胆碱酯酶(CHE)等多项生化指标进行检测,并分析两组患者不同阶段的HCV-RNA、抗-HCV阳性检测率。结果两组治疗前ALT、AST、CHE差异无统计学意义;治疗后2年高复制组ALT、AST分别为(75.21±12.38)U/L、(52.35±12.84)U/L高于低复制组(61.22±18.57)U/L、(31.32±8.64)U/L,差异均有统计学意义(P均0.05);治疗后高复制组CHE为(2867.48±123.56)U/L显著低于低复制组(3564.12±211.45)U/L(P0.05)。80例慢性丙型肝炎患者治疗前后不同阶段的HCV-RNA阳性率比较,均有统计学差异(P均0.05)。结论慢性丙型肝炎感染患者,一旦发生感染,抗-HCV指标会长时间的呈现阳性,而HCV-RNA水平会随着患者病情的发展而变化,其越高对患者的肝功能损伤越严重。
[Abstract]:Objective to investigate the dynamic monitoring characteristics of multiple biochemical indexes in patients with chronic hepatitis C. methods 80 patients with chronic hepatitis C infection were selected from December 2012 to December 2014. According to the serum viral load of patients with chronic hepatitis C infection, they were divided into high replication group (36 cases) and low replication group (44 cases). Several biochemical indexes, such as alanine aminotransferase (alt), aspartate aminotransferase (AST), cholinesterase (che), and so on, were detected. The HCV-RNAs and anti-HCV positive rates of the two groups were analyzed at different stages. Results there was no significant difference between the two groups before treatment. Two years after treatment, the alt of high replication group was 75.21 卤12.38 UP / L 52.35 卤12.84 U / L respectively, which was significantly higher than that of low replication group (61.22 卤18.57U / L 31.32 卤8.64U / L, P < 0.05), and the CHE of high replication group was 2867.48 卤123.56UL significantly lower than that of low replication group (3564.12 卤211.45ULP0.05.80 cases of chronic hepatitis C) before and after treatment. Conclusion in patients with chronic hepatitis C infection, the anti-HCV index will be positive for a long time, and the level of HCV-RNA will change with the development of the patient's condition. The higher the liver function, the more serious the injury.
【作者单位】：天津市泰达医院检验科;天津市塘沽传染病医院检验科;
【分类号】：R446.1;R512.63

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