FibroScan诊断慢性乙肝患者肝脏纤维化的临床应用研究

发布时间：2018-02-24 12:05

本文关键词： 瞬时弹性成像肝脏纤维化慢性乙型肝炎　出处：《安徽医科大学学报》2015年06期 　论文类型：期刊论文

【摘要】：目的评估瞬时弹性超声成像(Fibro Scan)在慢性乙型肝炎(CHB)患者肝脏纤维化诊断中的临床应用价值。方法选取进行肝脏穿刺活检的CHB患者185例,收集血常规、肝功能等血清学指标。同时患者应用Fibro Scan进行肝脏弹性测量值(LSM)测量,分析LSM与肝纤维化的相关性及其影响因素。结果以肝脏穿刺病理结果为金标准,Spearman等级相关性分析提示LSM与肝纤维化呈显著相关性(P0.05)。单因素方差分析提示天门冬氨酸氨基转移酶、碱性磷酸酶、血小板、凝血酶原时间百分活动度与LSM值呈相关性。受试者工作特性曲线(ROC)分析,S2~S4期诊断界值依次为6.0、9.75、14.2 k Pa,各阶段曲线下面积均0.95。双变量分析提示LSM值与升高的转氨酶呈显著相关性(P0.05)。ROC分析转氨酶升高组S1~S2期界值为6.25 k Pa,S3~S4期界值为15.3 k Pa。结论 Fibro Scan诊断CHB患者肝脏纤维化有较高的临床应用价值,但是受转氨酶影响大。
[Abstract]:Objective to evaluate the clinical value of fibro Scann in the diagnosis of hepatic fibrosis in patients with chronic hepatitis B. methods 185 CHB patients with liver biopsy were selected and blood routine was collected. At the same time, Fibro Scan was used to measure the liver elasticity. The correlation between LSM and hepatic fibrosis and its influencing factors were analyzed. Results according to the pathological results of liver puncture as the golden standard, the correlation between LSM and liver fibrosis was significant (P 0.05), and the single factor variance analysis suggested that aspartate aminotransferase. Alkaline phosphatase, platelets, There was a correlation between prothrombin time activity and LSM value. The diagnostic threshold value of S2S4 phase was 6.0 ~ 9.75 ~ 14.2 kPa. the area under each phase curve was 0.95.Bivariate analysis showed that LSM value was associated with elevated aminotransferase. There was a significant correlation between P0.05 and ROC in the analysis of transaminase in patients with elevated aminotransferase. The threshold of S _ 1 / S _ 2 was 6.25 k / s _ 3s _ 3 / S _ 4, which was 15.3kPa.Conclusion Fibro Scan has a high clinical value in diagnosing hepatic fibrosis in patients with CHB. But it is heavily affected by transaminase.
【作者单位】：安徽医科大学第一附属医院感染科;安徽医科大学第四附属医院感染科;
【基金】：国家自然基金(编号:81172737)
【分类号】：R512.62;R445.1

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