慢性乙肝4项临床指标联合检测在早期肝硬化快速筛查中的应用

发布时间：2018-02-25 03:01

本文关键词： 慢性乙肝临床检验指标早期肝硬化快速筛查　出处：《东南大学学报(医学版)》2017年05期 　论文类型：期刊论文

【摘要】：目的:为了快速筛查和发现乙肝早期肝硬化患者,制定个体化治疗方案,降低肝硬化和肝癌的发生率,方法:以白细胞(WBC)、血小板(PLT)、凝血酶原时间(PT)和前白蛋白(PA)为主要乙肝临床检验联合筛查指标。结果:通过统计分析研究表明,乙肝早期肝硬化患者的白细胞(3.2×10~9·L~(-1))、血小板(68.3×10~9·L~(-1))和前白蛋白(137.2 mg·L~(-1))等指标值均明显低于该3项指标的正常参考值下限(WBC值=4.0×10~9·L~(-1),PLT值=100.0×10~9·L~(-1),PA值=180.0 mg·L~(-1))和无早期肝硬化患者的临床检验指标值(WBC值=5.2×10~9·L~(-1),PLT值=136.0×10~9·L~(-1),PA值=196.7 mg·L~(-1))。对于PT,与无早期肝硬化患者PT参考值为12.8 s,而有早期肝硬化风险患者PT为16.4 s,存在3.4 s(3 s,有意义)显著差异值。结论:通过联合比较WBC、PLT、PT、PA等临床检验指标值可以快速筛查具有早期肝硬化风险的乙肝患者,且当这4个指标值均介于乙肝早期肝硬化风险指标值时,快速筛选才出现仅有的6%的正误筛率。
[Abstract]:Objective: in order to quickly screen and find patients with early cirrhosis of hepatitis B, to establish individualized treatment to reduce the incidence of liver cirrhosis and liver cancer. Methods: WBC, PLT, PTT and PAA were used as the main screening indexes of hepatitis B. results: statistical analysis showed that, The index values of leukocyte count (3.2 脳 109 路L ~ (-1), platelets 68.3 脳 10 ~ (9) 路L ~ (-1)) and prealbumin ~ (137.2 mg 路L ~ (-1)) in early cirrhosis of hepatitis B were significantly lower than those of the normal lower reference value and the WBC value of 4.0 脳 10 ~ (9) 路L ~ (-1) 路L ~ (1) of PLT in patients with early liver cirrhosis and in patients without early liver cirrhosis, the clinical examination index was 100.0 mg 路L ~ (-1) and 180.0 mg 路L ~ (-1) for patients with no early liver cirrhosis. The standard value of WBC was 5.2 脳 10 ~ (9) 路L ~ (-1) P _ (PLT) = 136.0 脳 10 ~ (9) 路L ~ (-1) P = 196.7 mg 路L ~ (-1). For PTT, the reference value of PT was 12.8 s compared with that of patients without early cirrhosis, while the value of PT was 16.4 s for patients with early cirrhosis and 3.4 s / 3 s for those at risk of early cirrhosis. Conclusion: it is significant to compare the values of PLTPTPA and so on. Clinical test index values can be used to quickly screen hepatitis B patients who are at risk of early cirrhosis. And when the four indexes were between the risk index of early hepatitis B cirrhosis, the only positive and wrong screening rate of 6% appeared in the rapid screening.
【作者单位】：苏州市第五人民医院传染科;
【分类号】：R512.62;R575.2

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