重组人干扰素联合薄芝糖肽治疗高甲胎蛋白慢性乙型肝炎的临床观察

发布时间：2018-03-04 04:38

本文选题：慢性乙型肝炎　切入点：甲胎蛋白　出处：《中国药房》2015年09期 　论文类型：期刊论文

【摘要】：目的:观察重组人干扰素联合薄芝糖肽治疗高甲胎蛋白(AFP)慢性乙型肝炎的疗效及安全性。方法:选择我院82例高AFP慢性乙型肝炎患者,随机均分为观察组和对照组。观察组患者采用重组人干扰素α-2b注射液300万U肌肉注射、每日1次,连用4周后改为500万U、隔日1次;并以薄芝糖肽4 ml加入5%葡萄糖注射液200 ml中静脉滴注,每日1次。对照组患者仅采用重组人干扰素α-2b注射液治疗,用法用量同观察组。两组疗程均为16周。比较两组患者治疗前后丙氨酸氨基转移酶(ALT)、乙型肝炎e抗原(HBe Ag)、乙型肝炎病毒脱氧核糖核酸(HBV-DNA)拷贝数和AFP的变化,并观察不良反应发生情况。结果:治疗后,观察组患者ALT复常率和HBe Ag转阴率均显著高于对照组,差异有统计学意义(P0.05);两组患者HBV-DNA拷贝数和AFP水平均显著低于本组治疗前,且观察组低于对照组,差异有统计学意义(P0.05)。观察组患者不良反应发生率显著低于对照组,差异有统计学意义(P0.05)。结论:重组人干扰素联合薄芝糖肽治疗高AFP慢性乙型肝炎较单用重组人干扰素疗效更好,可有效改善肝功能、抑制病毒增殖,且安全性较好。
[Abstract]:Objective: to observe the efficacy and safety of recombinant human interferon combined with Ganoderma lucidum glycopeptide in the treatment of chronic hepatitis B with high alpha fetoprotein (AFP). Methods: 82 patients with high AFP chronic hepatitis B in our hospital were selected. The patients in the observation group were injected with recombinant human interferon 伪 -2b injection 3 million U intramuscularly once a day for 4 weeks and then 5 million U, once every other day. The patients in the control group were treated with recombinant human interferon 伪 -2b injection. The dosage was the same as the observation group. The course of treatment was 16 weeks. The changes of alt, HBe, HBV-DNA and AFP were compared between the two groups before and after treatment. Results: after treatment, the rates of ALT normalization and HBe Ag negative conversion in the observation group were significantly higher than those in the control group (P 0.05), and the HBV-DNA copy number and AFP level in the two groups were significantly lower than those before the treatment. The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P 0.05). Conclusion: recombinant human interferon combined with ganoderma lucidum glycopeptide is more effective than recombinant human interferon in the treatment of chronic hepatitis B with high AFP, which can effectively improve liver function and inhibit virus proliferation.
【作者单位】：邯郸市传染病医院;
【分类号】：R512.62

【相似文献】