单纯疱疹病毒感染对房颤患者的影响分析

发布时间：2018-03-05 13:49

  本文选题：单纯疱疹病毒　切入点：心房颤动　出处：《中华医院感染学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨单纯疱疹病毒感染与心房颤动的关系,为临床诊治提供依据。方法选取2014年1月-2016年12月医院收治的房颤患者96例,其中阵发性房颤68例,持续性房颤28例。另选同期医院健康体检者100例为对照组;所有研究对象于清晨采集空腹血,检测HSV-1抗体和HSV-2抗体,C-反应蛋白(CRP)、胱氨酸蛋白酶抑制剂C(Cyc)和血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]。结果阵发性房颤组和持续性房颤组血清HSV-1抗体和HSV-2抗体水平均显著高于对照组(P0.01),阵发性房颤组和持续性房颤组血清HSV-1抗体和HSV-2抗体水平比较差异无统计学意义;阵发性房颤组和持续性房颤组血清HSV-1抗体阳性率、HSV-2抗体阳性率、CRP、Cyc、TC、TG和LDL-C水平均显著高于对照组,HDL-C水平显著低于对照组(P0.05),阵发性房颤组和持续性房颤组各指标比较差异均无统计学意义;血清HSV-1抗体和HSV-2抗体与CRP呈明显正相关性(r=0.669,P=0.012;r=0.531,P=0.018);血清HSV-1抗体和HSV-2抗体与Cyc呈明显正相关性(r=0.605,P=0.015;r=0.453,P=0.032)。结论 HSV感染可能通过炎症反应和影响血脂正常代谢等过程,直接或间接地参与房颤的形成过程。
[Abstract]:Objective to investigate the relationship between herpes simplex virus infection and atrial fibrillation, and to provide evidence for clinical diagnosis and treatment. Methods 96 patients with atrial fibrillation were selected from January 2014 to December 2016, including 68 patients with paroxysmal atrial fibrillation. 28 cases of persistent atrial fibrillation. 100 cases of health check-up in the same period were selected as control group. All the subjects collected fasting blood in the early morning. The levels of HSV-1 antibody and HSV-2 antibody C reactive protein (HSV-2), cystine protease inhibitor (cystine), and serum lipids were determined. Results the results of paroxysmal atrial fibrillation group were as follows: total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). The levels of serum HSV-1 antibody and HSV-2 antibody in patients with paroxysmal atrial fibrillation and persistent atrial fibrillation were significantly higher than those in control group (P 0.01). There was no significant difference in the levels of serum HSV-1 antibody and HSV-2 antibody between paroxysmal atrial fibrillation group and persistent atrial fibrillation group. Serum HSV-1 Antibody positive rate and HSV-2 Antibody positive rate in paroxysmal Atrial Fibrillation Group and persistent Atrial Fibrillation Group; the levels of TG and LDL-C in the serum HSV-2 antibody of patients with paroxysmal atrial fibrillation and persistent atrial fibrillation were significantly higher than those of the control group (P 0.05). The indexes of paroxysmal atrial fibrillation group and persistent atrial fibrillation group were lower than those of the control group. There was no significant difference between the two groups. There was a positive correlation between serum HSV-1 antibody and HSV-2 antibody and CRP. There was a positive correlation between serum HSV-1 antibody and HSV-2 antibody and Cyc. Conclusion HSV infection may be through inflammatory reaction and affect the normal metabolism of blood lipid. Participate directly or indirectly in the formation of atrial fibrillation.
【作者单位】： 锦州医科大学附属三院心血管内三科;锦州医科大学附属三院检验科;
【基金】：辽宁省教育科学“十二五”规划基金资助项目(JG15DB233)
【分类号】：R541.75;R752.11
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