慢性活动型EB病毒感染的致病机理研究进展

发布时间：2018-03-08 18:42

本文选题：EB病毒　切入点：慢性活动型EB病毒感染　出处：《生物化学与生物物理进展》2016年10期 　论文类型：期刊论文

【摘要】：慢性活动型EB病毒(Epstein Barr virus,EBV)感染(chronic active EBV infection,CAEBV)是一类EBV相关的T/NK淋巴细胞增殖性疾病(Epstein Barr virus-associated T/NK-cell lymphoproliferative diseases,EBV~+T/NK-cell LPD),以持续反复的类似传染性单核细胞增多症(infectious mononucleosis,IM)临床病征和EBV感染细胞的克隆性增殖为主要特征,在临床上具有较高的发病率和致死率.目前对于CAEBV与其他各类EBV相关的T/NK淋巴细胞增殖性疾病之间的界定以及致病机理的研究仍处于发展阶段,临床上对于该类疾病的治疗也无完全有效的手段.本文主要从EBV如何感染T/NK细胞、EBV相关的病毒学研究、机体自身遗传及免疫背景几方面,综述了目前对于CAEBV致病机理的研究进展,旨在为进一步研究提供思路和线索.
[Abstract]:Epstein Barr virus-associated T / NK-cell lymphoproliferative disease (Epstein Barr virus-associated T / NK-cell lymphoproliferative disease) Epstein Barr virus-associated / T / NK-cell lymphoproliferative disease (EBV ~ T / NK-cell LPDD) is a class of EBV associated T / NK lymphocytic proliferative disease (Epstein Barr virus-associated / T / NK-cell lymphoproliferative disease), characterized by persistent and repeated infectious mononucleosis monocytosis disease (infectious mononucleosis) and EBV infection in patients with chronic Epstein-Barr virus (Epstein-Barr virus / Epstein-Barr virus) infection (Epstein Barr virus-associated / T / NK-cell lymphoproliferative disease). The clonal proliferation of cells is the main characteristic. At present, the definition of CAEBV and other T / NK lymphocytic proliferative diseases associated with EBV and the pathogenesis of the disease are still in the developing stage. There is no completely effective method for the treatment of this kind of disease. This article mainly focuses on the virological study of how EBV infects T / NK cell EBV, the organism's own heredity and immune background. This paper reviews the current research progress on the pathogenesis of CAEBV in order to provide ideas and clues for further research.
【作者单位】：兰州大学生命科学学院;中国科学院遗传与发育生物学研究所;
【基金】：中国科学院重点部署项目(KFZD-SW-205)资助~~
【分类号】：R511

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