慢性HBV感染者血清甲状腺相关物质和IL-6的检测及其临床意义

发布时间：2018-03-11 13:32

本文选题：慢性乙型肝炎　切入点：乙型肝炎肝硬化　出处：《福建医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的研究慢性乙型肝炎病毒（Hepatitis BVirus，HBV）感染者血清甲状腺激素、抗甲状腺自身抗体及白细胞介素（interleukin，IL）-6水平变化及其临床意义。方法选取健康对照（HC）者18例、慢性乙型肝炎（CHB）患者65例和乙型肝炎肝硬化（HB-LC）患者34例，，应用电化学发光法分别检测并比较血清甲状腺激素水平、促甲状腺激素(TSH)、抗甲状腺相关抗体及IL-6水平。结果CHB组和HB-LC组患者抗甲状腺过氧化物酶抗体（TPOAb）、抗甲状腺球蛋白抗体（TGAb）、抗促甲状腺激素受体抗体（TRAb）和IL-6水平均显著高于HC组，而FT3均显著低于HC组；HB-LC组患者TRAb和IL-6水平明显高于CHB组患者，而TT3和TT4水平显著低于CHB组患者；血清IL-6水平与TT3、FT3呈负相关，而与TGAb、TRAb呈正相关。结论联合检测慢性HBV感染者血清甲状腺激素、抗甲状腺自身抗体及IL-6水平对病情评价和预后判断有一定的临床价值。
[Abstract]:Objective to study the changes and clinical significance of serum thyroid hormones, anti-thyroid autoantibodies and interleukin-interleukin-interleukin-interleukin-6 (IL-6) levels in patients with chronic hepatitis B virus (HBV) infection. Serum thyroid hormone levels in 65 patients with chronic hepatitis B (CHB) and 34 patients with hepatitis B cirrhosis (HB-LC) were detected and compared by electrochemiluminescence (ECL). Results the levels of anti-thyroid peroxidase antibody, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, anti-thyrotropin receptor antibody and IL-6 in CHB group and HB-LC group were significantly higher than those in HC group. The levels of TRAb and IL-6 in HB-LC group were significantly higher than those in CHB group, while the levels of TT3 and TT4 were significantly lower than those in CHB group, and the serum IL-6 level was negatively correlated with TT3FT3. Conclusion the combined detection of serum thyroid hormone, anti-thyroid autoantibody and IL-6 levels in patients with chronic HBV infection has some clinical value in evaluating the disease and judging the prognosis.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.62

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