中西医结合治疗乙型肝炎相关性肝衰竭临床疗效的Meta分析

发布时间：2018-03-14 01:51

本文选题：乙型肝炎　切入点：肝衰竭　出处：《湖南中医杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的:对中西医结合治疗乙型肝炎相关性肝衰竭的临床随机对照试验研究进行疗效与方法学质量评价,明确治疗的有效性及应用性。方法:电子数据库(Pub Med、Cochrane肝胆病组试验注册资料库、Cochrane图书馆对照试验注册库、中国知网、维普数据库、万方数字化期刊网、中国临床试验注册中心)中检索符合纳入标准的随机对照试验文献,时间范围为2000年1月至2016年12月;选取中药制剂联合西医干预措施治疗乙型肝炎相关性肝衰竭的临床随机对照研究。使用Cochrane协作网专用软件Review Manager 5.3进行数据统计分析。结果:66项研究共5851例患者纳入Meta分析,结果显示临床总有效率、病死率、MELD评分的中西医结合治疗作用明显优于单纯西医组(P0.00001)。结论:中西医结合治疗乙型肝炎相关性肝衰竭可提高临床疗效并降低病死率。
[Abstract]:Objective: to evaluate the efficacy and methodological quality of a randomized controlled trial in the treatment of hepatitis B associated liver failure with integrated Chinese and western medicine. Methods: the electronic database Pub Medus Cochrane hepatobiliary group trial registration database, the Cochrane Library controlled trial Registry, China knowledge Network, Weip Database, Wanfang Digital Journal Network, The literature of randomized controlled trials, which met the inclusion criteria, was retrieved from January 2000 to December 2016 in China Clinical trial Registry. A randomized controlled clinical study was conducted on the treatment of hepatitis B related liver failure with the intervention of traditional Chinese medicine preparation and western medicine. The data were analyzed by Review Manager 5.3, a special software of Cochrane cooperation network. Results 5851 patients were included in the Meta analysis in the study of #number0# 66 items. The results showed that the total clinical effective rate, mortality and meld score of combined Chinese and western medicine were significantly better than that of western medicine alone (P 0.00001). Conclusion: the treatment of hepatitis B related liver failure with combination of traditional Chinese and western medicine can improve the clinical efficacy and reduce the fatality rate.
【作者单位】：广州中医药大学;广州中医药大学第一附属医院;
【基金】：国家科技重大专项课题(编号:2011ZX09102-009) 广东省广州市卫生局医药卫生科技项目(编号:20172A011016)
【分类号】：R512.62;R575.3

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