直接抗人球蛋白试验阳性在慢性重型乙型肝炎患者贫血中的临床意义

发布时间：2018-03-16 19:19

  本文选题：乙型肝炎　切入点：慢性乙型肝炎　出处：《中国感染控制杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨直接抗人球蛋白试验(DAT)阳性在慢性重型乙型肝炎患者贫血中的临床意义。方法对30例健康人、30例慢性乙型肝炎(慢乙肝)患者和50例慢性重型乙型肝炎(慢重肝)患者红细胞相关参数及DAT进行检测,并对影响DAT阳性的临床相关因素进行分析。结果慢重肝患者红细胞计数、血红蛋白(Hb)浓度以及红细胞压积(HCT)均低于慢乙肝患者和健康组(P0.05),而慢重肝患者红细胞体积分布宽度(RDW)高于慢乙肝和健康组(P0.05);慢重肝患者、慢乙肝患者和健康组DAT阳性率分别为62.82%、13.33%和0。DAT阳性的慢重肝患者红细胞计数、Hb浓度和HCT均低于相应DAT阴性患者(均P0.05),RDW却高于DAT阴性慢重肝患者(P=0.001);慢重肝患者红细胞毛细管分离后,衰老红细胞的DAT阳性强度高于年轻红细胞DAT阳性强度(P0.001);在慢重肝患者中,DAT的阳性和阴性的患者在性别、年龄、丙氨酸氨基转移酶、总胆红素、补体C3、C-反应蛋白及是否并发糖尿病方面存在差异(均P≤0.05)。结论慢重肝患者贫血的产生可能与衰老红细胞吸附抗体所致的免疫性溶血有关。
[Abstract]:Objective to investigate the clinical significance of direct antiglobulin test (DAT-positive) in anemia in patients with chronic severe hepatitis B. methods 30 healthy people with chronic hepatitis B and 50 patients with chronic severe hepatitis B were enrolled in this study. RBC related parameters and DAT were measured in patients with chronic and severe liver. The related factors affecting DAT positive were analyzed. Results the red blood cell count in patients with chronic severe liver, The concentrations of HB and HCT were lower in patients with chronic hepatitis B and healthy persons than those in patients with chronic hepatitis B and healthy persons, while the RDWs of erythrocyte volume distribution in patients with chronic and heavy liver were higher than those in patients with chronic hepatitis B and healthy persons, while those in patients with chronic and severe liver were higher than those in patients with chronic hepatitis B and healthy persons. The positive rates of DAT in patients with chronic hepatitis B and healthy subjects were 62.82% and 0.DAT-positive, respectively. The red blood cell count HB and HCT in patients with chronic hepatitis B and healthy subjects were lower than those in patients with DAT negative (all P0.05rdw were higher than those in patients with DAT negative chronic and severe liver (P 0.001), red blood cell capillary separation in patients with chronic and severe liver was higher than that in patients with chronic and severe liver. The positive intensity of DAT in aging erythrocytes was higher than that in young erythrocytes (P 0.001). In patients with chronic liver disease, the positive and negative DAT levels were higher in sex, age, alanine aminotransferase, total bilirubin, total bilirubin, and alanine aminotransferase. There were significant differences in complement C3C- reactive protein and diabetes mellitus (all P 鈮，

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