布氏杆菌病146例临床分析

发布时间：2018-03-22 19:57

本文选题：布氏杆菌病　切入点：体征和症状　出处：《新疆医科大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：布氏杆菌病是一种由布氏杆菌引起的人畜共患传染病。世界各地均有分布，但以发展中国家高发[1]。探讨新疆地区布氏杆菌病的流行情况、临床症状、体征、相关检查及治疗结果。方法：对新疆医科大学第一附属医院2005年1月—2012年7月146例布病住院患者进行回顾性分析。结果:收集的146例布病患者平均年龄为41.6±14.2岁，其中80.1%为男性（男：女=4.03：1）。本地区布病4-8月高发；发病地区主要为塔城、阿勒泰等农牧区为主。在此患者中73例有明确的接触牛羊史（50%）。临床表现以发热为主（97.3%），同时伴有大汗（39.7%），肌肉骨关节疼痛（34.2%），部分患者查体可有脾肿大（28.8%）、肝肿大（14.4%），淋巴结肿大（11.6%）。实验室检查缺乏特异性。部分出现血沉（80.9%）、C-反应蛋白（83.7%）、类风湿因子（62.5%）等升高。在出现并发症患者中，降钙素原有不同程度的升高。治疗主要用福平+多西环素，利福平+喹酮类联合治疗为主，，1个疗程（6周）治愈率97.6%。治疗效果在不同年龄组及不同民族患者中无明显差别。结论：布氏杆菌病发病率逐年升高，新疆为高发地区，在诊治“不明原因发热”患者时应考虑该疾病的可能，并详细询问流行病学史，可提高诊断率，合理规范抗菌治疗。
[Abstract]:Objective: brucellosis is a zoonotic infectious disease caused by brucellosis. Methods: 146 inpatients with brucellosis were retrospectively analyzed from January 2005 to July 2012 in the first affiliated Hospital of Xinjiang Medical University. Results: the average age of 146 patients with brucellosis was 41.6 卤14.2 years old. Of these, 80.1% were male (male: female 4.03: 1). The incidence of brucellosis in this area was high from April to August, and the main area of the disease was Tacheng. Altay and other farming and pastoral areas are the main. 73 cases of this patient have clear contact with cattle and sheep history. The clinical manifestation is fever as the main part, accompanied by 39. 7%, muscle and bone pain, muscle and bone pain, muscle bone and joint pain, some patients can have splenomegaly 28. 8 points, hepatomegaly 14.4m, lymphoid swelling 14. 4%, lymphoid. No specificity was found in laboratory tests. Some of the patients with ESR 80.9 or 83.7A, rheumatoid factor 62.5 were found to have increased ESR in the patients with complications, and in the patients with complications, some of them were found to have increased erythrocyte sedimentation rate (ESR) 83.7g, rheumatoid factor (rheumatoid factor 62.5g) and so on. Increased calcitonin in different degrees. Treatment with Fupin doxycycline, The cure rate was 97.60.There was no significant difference in the curative effect among patients of different ages and nationalities. Conclusion: the incidence of brucellosis is increasing year by year and Xinjiang is a high incidence area. The possibility of this disease should be considered in the diagnosis and treatment of "fever of unknown origin", and the epidemiological history should be inquired in detail, which can improve the diagnostic rate and reasonably standardize the antibacterial treatment.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R516.7

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