长效干扰素α治疗176例慢性病毒性肝炎的不良反应分析

发布时间：2018-03-29 14:00

本文选题：干扰素-α　切入点：药物不良反应监测　出处：《中国医院药学杂志》2015年12期

【摘要】：目的:了解长效干扰素在慢性病毒性肝炎抗病毒治疗过程中出现的常见不良反应及罕见不良反应。方法:对近3年我院慢性病毒性肝炎患者在使用长效干扰素抗病毒治疗的过程中出现的药物不良反应进行回顾性调查分析。结果:176例患者共出现不良反应620例次,其中发热(56.8%)、肌肉酸痛(36.4%)、白细胞减少(81.8%)及流感样症状(44.3%)为长效干扰素α的常见不良反应;罕见的不良反应包括甲状腺功能异常、抑郁或精神异常、心脏毒性及间质性肺炎等。结论:在抗病毒及免疫调节治疗的过程中干扰素的不良反应发生率高,用药前有必要对患者进行相关的用药教育,督促患者定期返院进行各种相关检查,以便及时监测并发现严重的药物不良反应,根据病情调整剂量或停用。临床医师及药师应熟知干扰素可能引起的各种不良反应。
[Abstract]:Objective: to investigate the common adverse reactions and rare adverse reactions of long-acting interferon in the treatment of chronic viral hepatitis. Methods: in recent three years, patients with chronic viral hepatitis in our hospital were treated with long-acting interferon. Adverse drug reactions in the course of viral therapy were retrospectively investigated and analyzed. Results A total of 620 adverse reactions occurred in 176 patients. Fever (56.8%), muscle soreness (36.4%), leukopenia (81.8%) and flu-like symptoms (44.33.00%) are common adverse reactions of long-acting interferon 伪. Rare adverse reactions include abnormal thyroid function, depression or mental disorder. Conclusion: the incidence of adverse reactions of interferon in the course of antiviral and immunomodulatory therapy is high. Urge the patient to return to hospital regularly to carry out all kinds of relevant examinations in order to monitor and detect serious adverse drug reactions, adjust the dosage or stop according to the condition. Clinicians and pharmacists should be familiar with all kinds of adverse reactions that may be caused by interferon.
【作者单位】：中山大学附属第三医院药学部;中山大学附属第三医院心内科;武汉市医疗救治中心;
【分类号】：R512.6

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