替考拉宁治疗血液病患者革兰阳性菌菌血症的疗效研究

发布时间：2018-03-29 22:30

本文选题：替考拉宁　切入点：血液病　出处：《中华医院感染学杂志》2015年18期

【摘要】：目的探讨替考拉宁治疗血液病患者革兰阳性菌菌血症的有效性和安全性,为临床治疗提供参考依据。方法回顾性分析2012年1月-2015年4月45例应用替考拉宁治疗的血液病革兰阳性菌菌血症患者的临床资料,所有患者均在血培养检查后给予经验性抗感染治疗,其中11例患者初始治疗应用替考拉宁,34例患者血培养革兰阳性菌感染加用替考拉宁治疗,评价替考拉宁在治疗中的疗效和安全性;采用SPSS17.0统计软件对数据进行统计分析。结果 45例患者中治愈21例、显效18例,总有效率为86.7%;治疗过程中发生不良反应2例,总不良反应发生率4.4%,均表现为皮疹,经对症治疗后好转;治疗期间4例患者死亡,均因呼吸衰竭,1例治疗过程中复查血培养替换为大肠埃希菌,2例分别合并大肠埃希菌和嗜麦芽寡养单胞菌感染;10例患者加用抗真菌治疗后体温降至正常。结论替考拉宁治疗血液病患者革兰阳性菌菌血症疗效确切,安全性高,但应重视病程中其他病原菌感染的可能。
[Abstract]:Objective to investigate the efficacy and safety of teicoplanin in the treatment of Gram-positive bacteremia in patients with hematologic diseases. Methods the clinical data of 45 patients with Gram-positive bacteremia of hematological diseases treated with teicoplanin from January 2012 to April 2015 were analyzed retrospectively. All the patients were treated with empirical anti-infective therapy after blood culture examination. Among them, 11 patients were treated with teicoplanin in the initial treatment and 34 patients were treated with teicoplanin plus teicoplanin for the infection of Gram-positive bacteria in blood culture. Results 21 cases were cured, 18 cases were effective, the total effective rate was 86.7%, and 2 cases had adverse reactions during the treatment, the efficacy and safety of teicoplanin in the treatment were evaluated, and the data were analyzed by SPSS17.0 statistical software, the results showed that 21 cases were cured, 18 cases were effective, and the total effective rate was 86.7%. The incidence of total adverse reactions was 4.4, all of them showed skin rash, improved after symptomatic treatment, and 4 patients died during the treatment. Blood culture was replaced by Escherichia coli in 2 patients with acute respiratory failure. 10 patients with infection of Escherichia coli and altotrophomonas maltophilia were treated with antifungal therapy, and their body temperature decreased to normal after antifungal therapy. Conclusion\\\. Coranine was effective in treating Gram-positive bacteremia in patients with hematologic diseases. Safety is high, but attention should be paid to the possible infection of other pathogens in the course of the disease.
【作者单位】：郑州大学第一附属医院血液科;
【基金】：国家自然科学基金资助项目(81000224)
【分类号】：R55;R515.3

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