桂西地区配偶间HIV传播及相关影响因素分析

发布时间：2018-04-04 16:35

本文选题：艾滋病　切入点：单阳配偶　出处：《现代预防医学》2017年07期

【摘要】：目的了解艾滋病配偶间HIV的传播并探讨其相关影响因素。方法采取动态队列研究的方法,通过现场招募百色市202对艾滋病单阳配偶为研究对象,每6个月对患者进行一次随访并对其阴性的配偶进行HIV检测,运用100人年阳转率来计算配偶间HIV的传播率,Kaplan-Meier分析HIV阴性的配偶仍保持阴性的概率,含依时协变量COX比例风险模型分析配偶间HIV传播的相关影响因素。结果单阳配偶中HIV患者平均年龄37.66±11.61岁,基线CD_4~+♂计数均值314.30±215.99个/mm~3,中位随访时间35个月(IQR:16-52),患者以男性、45岁以下、壮族、初中文化、农民及农民工、农村居住和异性性途径感染为主。随访期间共计14例阴性配偶发生了HIV阳转,阳转率为2.21/100人年,配偶1~6年累积HIV阳转率分别为2.11%、5.29%、7.75%、8.92%、8.92%、12.88%。经含依时协变量COX比例风险模型分析结果显示,患者职业(AHR=16.28,95%CI:1.47-180.33)、配偶结果告知时间(AHR=0.10,95%CI:0.02-0.57)和安全套使用频率(AHR=0.02,95%CI:0.00-0.19)与配偶间HIV传播存在统计学关联,患者经HIV确诊后6个月Qg及时告知配偶结果的HIV传播风险降低了90%,配偶性行为时每次均使用安全套的HIV传播风险则减少了98%。结论加强咨询检测服务,及时告知配偶HIV检测结果,发生性行为时坚持正确使用安全套,可有利于预防配偶间经性传播HIV。
[Abstract]:Objective to understand the HIV transmission between spouses of HIV and discuss the related factors. Methods the dynamic cohort study, through on-site recruitment Baise 202 of HIV positive spouses as the research object, once every 6 months follow-up of patients and the negative spouses of HIV detection, using the spread of 100 person years of seroconversion to calculate the rate of spouse rate of HIV, Kaplan-Meier of HIV negative spouses remain negative probability, containing time-dependent covariate COX proportional hazard model analysis of the influence factors of HIV transmission between spouses. The results of the single spouse in HIV patients with a mean age of 37.66 + 11.61 years, baseline CD_4~+ male count average of 314.30 + 215.99 /mm~3, the median follow-up time was 35 months (IQR:16-52), with 45 years of age, male, Zhuang, junior middle school education, farmers and migrant workers, rural living and heterosexual infection. During the follow-up period, a total of 14 cases. The spouse had HIV seroconversion, seroconversion rate was 2.21/100 years, 1~6 years cumulative spouse HIV seroconversion rates were 2.11%, 5.29%, 7.75%, 8.92%, 8.92%, 12.88%. after covariates COX proportional hazard model analysis showed that in time, patient occupation (AHR=16.28,95%CI:1.47-180.33), the spouse (AHR=0.10,95%CI:0.02-0.57) and the time of disclosure condom use frequency (AHR=0.02,95%CI:0.00-0.19) were significantly associated with the HIV transmission between spouses, with risk of transmitting HIV HIV 6 months after diagnosis of Qg results promptly inform the spouse is reduced by 90%, the spread of HIV risk behavior of spouse when using condoms every time was decreased by 98%. conclusion to strengthen counseling and testing services, HIV test results promptly inform the spouse during sex, adhere to the correct use of condoms, which is conducive to the prevention of sexual transmission between spouses HIV.

【作者单位】：百色市疾病预防控制中心;百色市卫生监督所;右江民族医学院公共卫生与管理学院;
【基金】：百色市科技计划项目(百科计140801-3)
【分类号】：R512.91;R181.3

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