护肝药对抗结核药物性肝损害患者的预防作用评价

发布时间：2018-04-09 06:17

本文选题：护肝药　切入点：异烟肼　出处：《抗感染药学》2016年06期

【摘要】：目的:评价护肝药对抗结核药物性肝损害(ATDH)患者的预防作用。方法:选取2014年9月—2015年10月接受异烟肼、利福平、吡嗪酰胺和乙胺丁醇抗结核药物治疗的结核患者300例,随访3月,并检测其实验室肝功能各指标。结果:其中287例患者占95.67%的结核患者预防性使用护肝药物,预防性护肝药物主要有益肝灵、水飞蓟宾、甘草酸制剂、双环醇、葡醛内酯和还原性谷胱甘肽等;预防性使用护肝药的患者肝损害发生率为3.83%(11/287),与文献报道的抗结核药物性肝损害的发生率为3%~10%,经比较两者之间的差异无统计学意义(χ~2=0.419,P0.05)。结论:护肝药物对抗结核药物性肝损害的预防意义不大,应根据患者基础情况确定是否需要预防性使用护肝药。
[Abstract]:Objective: to evaluate the preventive effect of liver protective drugs on patients with tuberculous drug-induced liver injury (ATDH).Methods: 300 tuberculosis patients treated with isoniazid, rifampicin, pyrazinamide and ethambutanol from September 2014 to October 2015 were selected and followed up for 3 months.Results: two hundred and eighty-seven patients (95.67%) were treated with liver protective drugs. The main preventive drugs were Yiganling, silybin, glycyrrhizic acid, bicyclic alcohol, aldehydes lactone and reductive glutathione.The incidence of liver damage in patients with prophylactic use of antituberculotic drugs was 3.833 / 287g, and that of anti-tuberculosis drugs was 3 / 10. There was no significant difference between the two groups (蠂 ~ (2 +) 2 ~ (0.419)) (P ~ (0.05)).Conclusion: it is of little significance to prevent liver damage caused by tuberculosis drugs. It is necessary to determine the need for preventive use of liver protection drugs according to the basic conditions of patients.
【作者单位】：江西省胸科医院药剂科;
【分类号】：R52;R575

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