中国2014年脊髓灰质炎实验室网络的运转与评价

发布时间：2018-04-16 10:31

本文选题：脊髓灰质炎网络 + 运转　；参考：《中国疫苗和免疫》2017年01期

【摘要】：目的评价中国(未包括香港、澳门特别行政区和台湾地区,下同)2014年脊髓灰质炎(脊灰)实验室网络(Polio Laboratory Network,PLN)运转情况,为中国维持无脊灰状态提供病毒学依据。方法对中国急性弛缓性麻痹(Acute flaccid paralysis,AFP)病例监测信息报告管理系统中31个省份报告的AFP病例和国家脊灰实验室(National Polio Laboratory,NPL)的监测数据进行分析,对PLN的各项运转指标进行评价。结果 2014年中国PLN共报告5 751例AFP病例,收到5 688例AFP病例的11 363份粪便标本;14天内双份粪便标本的采集率为92.16%,合格粪便标本采集率为91.65%,病毒分离结果 18天内反馈率为97.62%。从5 688例粪便标本中132例(2.32%)分离到脊灰病毒(Poliovirus,PV);590例(10.37%)分离到非脊灰肠道病毒(NPEV)。2014年NPL收到省级脊灰实验室送检的分离自AFP病例及其接触者、非AFP病例、健康人的292株L20 B细胞阳性分离物,262株为PV,21株为NPEV,9株为非肠道病毒(Non-enterovirus,NEV)。262株PV中,7株为疫苗衍生脊灰病毒(Vaccine-derived poliovirus,VDPV),来自内蒙古、山西、河北和湖南;未发现脊灰野病毒(Wild poliovirus,WPV)。从脊灰病毒外环境监测采集的污水标本中分离到4株VDPV。2014年NPL和31个省级CDC脊灰实验室都通过了世界卫生组织(WHO)粪便标本肠道病毒的新检测流程的能力验证标本考核。NPL和8个省级CDC脊灰实验室接受并通过了WHO现场评估认证,其他省级实验室接受了信函认证。结论中国PLN 2014年运转正常,未发现WPV,为维持中国无脊灰状态、早期发现VDPV或VDPV病例、早期采取应对措施阻断其传播提供了重要的病毒学依据。
[Abstract]:Objective to evaluate the operation of Polio Laboratory Network (PLN) in China (excluding Hong Kong, Macao Special Administrative region and Taiwan) in 2014, and to provide virological evidence for maintaining poliomyelitis in China.Methods the data of AFP cases reported in 31 provinces and National Polio Laboratory-NPLs of National Polio Laboratory in China acute flaccid paralysis (AFP) case monitoring information reporting system were analyzed, and the operation indexes of PLN were evaluated.Results in 2014, 5 751 cases of AFP were reported by PLN in China, 11 363 stool specimens of 5 688 cases of AFP were received in 2014. The collection rate of double stool specimens was 92.16 in 14 days, the collection rate of qualified stool specimens was 91.65 and the feedback rate of virus isolation results within 18 days was 97.62.Poliovirus PVV (590 cases) were isolated from 5 688 fecal specimens. (NPL received AFP cases from provincial polio laboratories and their contacts, non- cases in 2014.292 strains of L20B cell positive isolates of healthy people, including 21 strains of PVN, 21 strains of NPEV, 9 strains of non-enterovirus.262 strains of PV, 7 strains of vaccine-derived poliovirusus virus (VDPVN), from Inner Mongolia, Shanxi, Hebei and Hunan, and no wild poliovirus wild poliovirusus PVV.Four strains of VDPV.2014 annual NPL and 31 provincial CDC polio laboratories were isolated from sewage samples collected from the external environment monitoring of poliovirus. All of them passed the new detection procedure of the World Health Organization (WHO) fecal specimens.Nuclear. NPL and 8 provincial CDC polio laboratories accepted and passed WHO field assessment certification.Other provincial laboratories were certified by correspondence.Conclusion PLN in China has not been found in 2014, which provides an important virological basis for the maintenance of poliomyelitis in China, the early detection of VDPV or VDPV cases and the early adoption of countermeasures to block their transmission.
【作者单位】：中国疾病预防控制中心病毒病预防控制所国家卫生和计划生育委员会医学病毒学和病毒病重点实验室世界卫生组织西太平洋区脊髓灰质炎参比实验室;中国疾病预防控制中心免疫规划中心;
【基金】：行使WHO西太区脊灰参比实验室职能,2014年国家卫生和计划生育委员会疾病控制专项
【分类号】：R512.4

【相似文献】