2011-2015年张家港市痰培养阳性结核病的耐药分析

发布时间：2018-04-19 01:12

本文选题：肺结核 + 分支杆菌　；参考：《现代预防医学》2017年03期

【摘要】：目的描述张家港市2011年至2015年痰培养阳性的结核病患者的耐药情况,为制定有效的耐药结核病防控策略提供理论依据。方法对2011年1月至2015年11月张家港市临床登记并痰培养阳性的肺结核患者进行一线抗结核药物敏感试验,同时收集人口学和临床资料,进行耐药率分析。结果在获得的294株结核分枝杆菌中,共有93株为耐药菌株,总耐药率31.6%,初、复治患者耐药率为22.2%、57.7%,差异有统计学意义(χ2=33.34;P0.001);总耐多药率为6.1%,初治患者中未发现耐多药菌株,复治患者耐多药率为23.1%。初治患者以单耐药为主,复治患者以多耐药和耐多药为主。结论张家港市痰培养阳性结核病患者的耐药结核病和耐多药结核病患病率皆处在较高水平。需对初、复治患者根据药敏结果和治疗史做好分类管理,制订合理化疗方案,从而提高治疗效果,有效控制耐药结核病的产生和传播。
[Abstract]:Objective to describe the drug resistance of tuberculosis patients with positive sputum culture from 2011 to 2015 in Zhangjiagang City, and to provide theoretical basis for the formulation of effective drug resistant TB prevention and control strategy.Methods from January 2011 to November 2015, the tuberculosis patients with positive sputum culture and clinical registration in Zhangjiagang City were tested with first-line anti-tuberculosis drug sensitivity test. The demographics and clinical data were collected and the drug resistance rate was analyzed.Results among 294 strains of Mycobacterium tuberculosis, 93 strains were drug-resistant, the total resistance rate was 31.6%. At the beginning of treatment, the drug resistance rate of patients with recurrent treatment was 22.2and 57.7.The difference was statistically significant (蠂 ~ (2 +) 33.34 (P 0.001)), and the total multi-drug resistance rate was 6.1.There were no multidrug resistant strains in the initial treatment.The rate of multi-drug resistance was 23. 1%.The primary patients were single-resistant and the relapse-treated patients were multi-drug-resistant and multi-drug-resistant.Conclusion the prevalence of both MDR-TB and MDR-TB in patients with sputum culture positive in Zhangjiagang City is at a high level.In order to improve the therapeutic effect and control the occurrence and spread of drug-resistant tuberculosis it is necessary to classify the patients according to the results of drug sensitivity and the history of treatment and make a reasonable chemotherapy plan.
【作者单位】：江苏省张家港市疾病预防控制中心;江苏省疾病预防控制中心;
【基金】：国家科技重大专项“江苏省防治艾滋病、病毒性肝炎和结核病等重大传染病规模化现场流行病学和干预研究”(2013ZX10004-905) 苏州市2013年度科技发展计划“苏南地区耐药结核病预警模型研究”(SYSD2013008)
【分类号】：R52

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