头孢曲松钠联合胸腺五肽治疗早期宫颈癌合并梅毒的疗效观察

发布时间：2018-04-19 02:06

本文选题：头孢曲松钠 + 胸腺五肽　；参考：《中国地方病防治杂志》2017年03期

【摘要】：目的分析头孢曲松钠联合胸腺五肽治疗早期宫颈癌合并梅毒的效果。方法 100例早期宫颈癌合并梅毒患者按治疗方案不同用双盲法分为对照组(青霉素钠联合苄星青霉素)和观察组(头孢曲松钠联合胸腺五肽)。记录治疗1周患者皮损消退率,治疗前及治疗2周后血清T细胞水平;以12、24、48周为时间点对比两组快速血浆反应素环状卡片实验(RPR)转阴率、梅毒复发率、梅毒治疗有效率;记录0.5、1年生存率。结果 1周时观察组皮损消率高于对照组;治疗2周时CD4+和CD3+高于对照组,CD8+低于对照组;12、24、18周RPR转阴率均高于对照组,梅毒复发3例低于对照组,梅毒治疗有效率高于对照组;1年生存率高于对照组(P均0.05)。结论头孢曲松钠联合胸腺五肽治疗早期宫颈癌合并梅毒能快速消退皮损,改善T细胞水平,近期能提高RPR转阴率,降低梅毒复发率,能提高1年生存率。
[Abstract]:Objective to analyze the effect of ceftriaxone sodium combined with thymic pentapeptide in the treatment of early cervical cancer with syphilis.Methods 100 patients with early cervical cancer complicated with syphilis were divided into two groups: control group (penicillin sodium combined with benzylpenicillin) and observation group (ceftriaxone sodium combined with thymopeptide).The regression rate of skin lesion, the serum T cell level before treatment and 2 weeks after treatment were recorded, and the rapid plasma RPR-negative rate, the recurrence rate of syphilis and the effective rate of syphilis treatment were compared between the two groups.The 0.5 and 1 year survival rates were recorded.Results the skin lesion elimination rate in the observation group was higher than that in the control group at 1 week, the CD4 and CD3 were higher in the observation group than in the control group at 2 weeks after treatment, and the RPR negative rate in the control group at 18 weeks was lower than that in the control group.The effective rate of syphilis treatment was higher than that of control group, and the 1 year survival rate was higher than that of control group (P < 0.05).Conclusion Ceftriaxone sodium combined with thymic pentapeptide in the treatment of early cervical cancer with syphilis can quickly dissipate lesions, improve T cell level, increase RPR negative rate, reduce syphilis recurrence rate and improve 1 year survival rate in the near future.
【作者单位】：鄂尔多斯妇产医院;鄂尔多斯市干部保健中心;
【基金】：深圳市医学科研项目(编号:200603116)
【分类号】：R737.33;R759.1

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