干扰素刺激基因在丙型肝炎病毒复制中的作用

发布时间：2018-04-22 01:25

本文选题：干扰素 + 干扰素刺激基因　；参考：《中国输血杂志》2015年10期

【摘要】：丙型肝炎(简称丙肝)由丙型肝炎病毒(HCV)感染所致,约80%感染者可发展成慢性肝炎,甚至肝硬化和肝癌。目前,丙肝的防治仍无有效的疫苗,临床治疗丙肝主要应用干扰素结合利巴韦林联合疗法,但治疗后HCV有效应答率不高,并伴有明显的副作用。目前对干扰素抗HCV作用的具体机制还不清楚。干扰素通过各种信号通路最终激活干扰素刺激基因(ISGs)的表达,其表达产物称为干扰素诱导蛋白,其中与HCV复制相关的主要有PKR、Mx A、ISG15、USP18等。近几年ISGs的抗HCV作用和机制的研究已经有了很大的突破,ISGs在抗HCV的作用也越来越受到人们重视。了解清楚ISGs对HCV的作用,对于研制新的抗病毒药物及提出新的抗病毒策略具有重要意义。
[Abstract]:Hepatitis C (hepatitis C) is caused by hepatitis C virus (HCV) infection. About 80% of infected patients can develop chronic hepatitis, even liver cirrhosis and liver cancer. At present, the prevention and treatment of hepatitis C is still not effective vaccine, clinical treatment of hepatitis C mainly used interferon combined with ribavirin combination therapy, but the effective response rate of HCV after treatment is not high, with obvious side effects. At present, the specific mechanism of the anti-HCV effect of interferon is not clear. Interferon activates the expression of interferon stimulating gene (ISGs) through various signal pathways, and its expression product is called interferon inducible protein, in which HCV replication is mainly associated with PKRMx Agni ISG15 USP18 and so on. In recent years, more and more attention has been paid to the anti- effect and mechanism of ISGs. Understanding the effect of ISGs on HCV is of great significance for the development of new antiviral drugs and the development of new antiviral strategies.
【作者单位】：中国医学科学院北京协和医学院输血研究所;
【基金】：国家自然科学基金面上项目(81471956,91442128) 四川省科技厅国际合作项目(2013HH0013);四川省科技厅应用基础研究项目(2013JY0048)
【分类号】：R456;R512.63

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