慢性丙型肝炎病毒感染者血清自身抗体的检测及意义

发布时间：2018-04-22 10:34

  本文选题：丙型肝炎 + 病毒　； 参考：《北京医学》2013年03期

【摘要】：目的探讨慢性丙型肝炎病毒(HCV)感染者血清中自身抗体检测的临床意义。方法对119例慢性HCV感染者及40例健康体检者的血清标本进行抗核抗体(ANA)、抗可提取性核抗原(ENA)抗体、类风湿因子(RF)检测,比较其阳性率,并分析自身抗体与年龄、性别、民族、肝功能指标及病毒复制的关系。结果 119例慢性HCV感染者中有64例检测出至少1项自身抗体,阳性率为53.8%,40例健康对照者中有3例检测出至少1项自身抗体,阳性率为7.5%,两组检出率的差异有统计学意义(P0.05)。HCVRNA阳性组中自身抗体检出率为64.6%,HCVRNA阴性组检出率为40.7%,两组检出率的差异有统计学意义(P0.05)。自身抗体阳性组与阴性组的性别、民族比较,差异无统计学意义(P0.05),年龄≥40岁患者的构成比差异有统计学意义(P0.05)。自身抗体阳性组丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素均高于阴性组(P0.05)。结论 HCV感染能诱导自身免疫反应,产生多种自身抗体,自身抗体的检出率与年龄和病毒复制有关,自身免疫可能是HCV感染后组织损伤的重要因素。HCV感染者有必要做自身抗体检测。
[Abstract]:Objective to investigate the clinical significance of serum autoantibodies in patients with chronic hepatitis C virus (HCV) infection. Methods Serum samples of 119 patients with chronic HCV infection and 40 healthy controls were tested for antinuclear antibody (Ana), anti-extractable nuclear antigen (na) antibody and rheumatoid factor (RF). The relationship between liver function and virus replication. Results 64 out of 119 cases of chronic HCV infection detected at least one autoantibody, the positive rate was 53.8% and 3 out of 40 healthy controls detected at least 1 autoantibody. The positive rate was 7.5. The difference between the two groups was statistically significant. The detection rate of autoantibody in the positive group was 64.6and the positive rate of HCV RNA was 40.7. The difference between the two groups was statistically significant (P 0.05). There was no significant difference in sex and nationality between autoantibody positive group and negative group (P 0.05), but there was significant difference in composition ratio of patients aged 鈮，

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