浙江省宁波市2004—2015年麻疹流行病学和基因型特征分析

发布时间：2018-04-24 15:35

  本文选题：麻疹 + 流行病学特征　； 参考：《中国公共卫生》2017年08期

【摘要】：目的了解浙江省宁波市2004—2015年麻疹流行病学特征及野毒株的基因型特征,为制定防控对策提供参考依据。方法收集宁波市2004年1月—2015年12月麻疹发病监测数据及各县(市、区)报告的麻疹野毒株样本,采用逆转录-聚合酶链反应(RT-PCR)进行扩增,对PCR产物进行序列测定和分析。结果宁波市2004—2015年麻疹发病率依次为9.93/10万、21.09/10万、2.46/10万、12.73/10万、33.38/10万、4.10/10万、2.41/10万、0.93/10万、6.60/10万、2.11/10万、2.30/10万、2.74/10万,麻疹发病率总体呈下降趋势(χ_(趋势)~2=2 743.496,P0.01);麻疹全年均有发病,以2~5月为发病高峰,病例数占总发病数的66.74%;宁波市11个市(区、县)麻疹均有发病,发病率居于前3位的地区分别为海曙区520例(13.81/10万)、江北区485例(13.33/10万)及江东区450例(12.19/10万);麻疹8月龄、8月龄~7岁、8~14岁、15~19岁和≥20岁病例构成比分别为23.13%、20.89%、4.02%、6.40%和45.56%;宁波市2004—2015年共分离到麻疹野毒株90株,其中11株为B3基因亚型,79株为H1基因型(H1a基因亚型73株,H1b基因亚型6株)。结论宁波市2004—2015年麻疹发病率总体呈下降趋势;H1a亚型为该地区麻疹优势基因型。
[Abstract]:Objective to investigate the epidemiological characteristics of measles and genotype of wild strains in Ningbo, Zhejiang Province from 2004 to 2015, and to provide a reference for the prevention and control of measles. Methods the surveillance data of measles incidence from January 2004 to December 2015 in Ningbo and the samples of measles wild strains reported from counties (cities and districts) were collected and amplified by reverse transcription-polymerase chain reaction (RT-PCR). The PCR products were sequenced and analyzed. Results the incidence of measles in Ningbo from 2004 to 2015 was 99.3 / 100,000,000 or 21.0910 / 100 000 or 24.6 / 100,000.The incidence rate of measles was 33.38 / 100,000,000 or 410,000.10,000,441 / 100, and 0.93.1 / 100000 / 66,6010 / 10000 or 21,100 / 100,000.The overall incidence of measles showed a downward trend (蠂 ~ (+)) (蠂 ~ (+)) the incidence of measles showed a downward trend (蠂 ~ (+)); measles occurred all year, and the peak incidence was in February and May, the highest incidence rate was in the whole year (蠂 ~ (2) 2 743 496% (P < 0.01)), and the incidence of measles was the highest in the whole year, and the peak incidence rate was in February to May (P < 0.05). The number of cases accounted for 66.74 of the total incidence; measles occurred in all 11 cities (districts and counties) of Ningbo. The incidence of measles in the top 3 areas were 520 cases of Haishu District (13.81%), 485 cases of Jiangbei District (133,300%) and 450 cases of Jiangdong District (12.19% / 100 000). The proportions of measles in 814 years old, 814 years old, 1514 years old, 19 years old and 鈮，

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