不同真菌感染对降钙素原的差异与疾病预后的关系

发布时间：2018-04-29 05:19

本文选题：真菌感染 + 降钙素原　；参考：《中华医院感染学杂志》2015年09期

【摘要】：目的观察不同真菌感染降钙素原的差异性,并对其与疾病预后的相关性进行分析。方法选取2012年6月-2013年6月于ICU就诊的危重病患者54例,根据危险评分分组,非危重组24例、危重组25例、极危重组5例;研究不同感染部位血清降钙素原水平、不同菌株感染血清降钙素原水平以及降钙素原与疾病预后的相关性。结果 54例真菌感染患者中肺部感染26例占48.15%、消化道感染12例占22.21%、泌尿道感染9例占16.67%、血流感染9例占12.96%;不同感染部位血清降钙素原水平具有一定差异性,其中血清降钙素原水平较其他部位明显偏高,差异有统计学意义(P0.05);共培养出病原菌86株,其中白色假丝酵母菌占55.81%,热带假丝酵母菌占37.21%,克柔假丝酵母菌占6.98%,降钙素原水平差异无统计学意义;随着危重程度的不断升高,降钙素原水平逐渐增高,组间差异有统计学意义(P0.05),PCT与危重评分呈正相关(P0.05)。结论降钙素原对真菌感染的诊断有重大意义,但不同菌株间差异无显著性,其水平与疾病危重程度密切相关。
[Abstract]:Objective to observe the difference of procalcitonin in different fungal infections and analyze its correlation with disease prognosis. Methods from June 2012 to June 2013, 54 critically ill patients with ICU were divided into three groups according to the risk score: non-risk recombination (24 cases), critical recombination (25 cases) and extremely dangerous recombination (5 cases), and the level of serum procalcitonin in different infection sites was studied. The serum procalcitonin level and the relationship between procalcitonin level and disease prognosis in different strains. Results among 54 patients with fungal infection, 26 cases were pulmonary infection (48.15), 12 cases were digestive tract infection (22.21), 9 cases were urinary tract infection (16.67%), and 9 cases were blood stream infection (12.96%). The serum procalcitonin level was significantly higher than that of other parts, and the difference was statistically significant (P 0.05), and 86 strains of pathogenic bacteria were cultured. Among them, 55.81% were Candida albicans, 37.21% were Candida tropicalis, 6.98 were Candida cerevisiae, and there was no significant difference in procalcitonin level. There was a positive correlation between PCT and critical score (P 0.05). Conclusion Procalcitonin is of great significance in the diagnosis of fungal infection, but there is no significant difference among different strains. The level of procalcitonin is closely related to the severity of the disease.
【作者单位】：南阳市第二人民医院检验科;河南省高等学校临床医学重点学科开放实验室;
【基金】：河南省卫生厅科研基金资助项目(201203015)
【分类号】：R519

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