带状疱疹继发感染的病原学特点及危险因素分析

发布时间：2018-05-06 17:22

  本文选题：带状疱疹 + 感染　； 参考：《中华医院感染学杂志》2017年09期

【摘要】：目的分析带状疱疹继发感染的病原学特点及危险因素,为临床预防和治疗提供参考依据。方法选取医院2014年12月-2016年9月收治的带状疱疹患者953例,统计病原菌分布及分析带状疱疹继发感染的危险因素。结果 87例带状疱疹继发感染患者共分离培养出病原菌84株,其中革兰阴性菌64株占76.2%,革兰阳性菌17株占20.2%,真菌3株占3.6%;肺炎克雷伯菌对庆大霉素、阿米卡星、美罗培南耐药率分别为85.7%、80.9%、95.2%,铜绿假单胞菌对庆大霉素、阿米卡星、美罗培南耐药率分别为66.7%、83.3%、88.9%,大肠埃希菌对庆大霉素、阿米卡星、美罗培南耐药率分别为60.0%、93.3%、100.0%,表皮葡萄球菌对红霉素、青霉素、万古霉素耐药率分别为83.3%、66.7%、66.7%,金黄色葡萄球菌对红霉素、青霉素、万古霉素耐药率分别为80.0%、80.0%、60.0%,凝固酶阴性葡萄球菌对红霉素、青霉素、万古霉素耐药率分别为80.0%、60.0%、100.0%;单因素分析显示,带状疱疹继发感染与年龄≥50岁、皮损面积≥500cm2、未接受规范治疗及有水痘带状疱疹病毒接触史具有相关性(P0.05);多因素logistic回归分析结果显示,年龄≥50岁、皮损面积≥500cm2、未接受规范治疗为带状疱疹继发感染的独立危险因素。结论革兰阴性菌为带状疱疹继发感染的主要病原菌,年龄≥50岁、皮损面积≥500cm2、未接受规范治疗为带状疱疹继发感染的危险因素,针对病原菌特点和危险因素,采取相应措施,是降低带状疱疹继发感染的关键。
[Abstract]:Objective to analyze the etiological characteristics and risk factors of herpes zoster secondary infection and to provide reference for clinical prevention and treatment. Methods 953 patients with herpes zoster were selected from December 2014 to September 2016. The distribution of pathogenic bacteria and the risk factors of secondary infection of herpes zoster were analyzed. Results A total of 84 strains of pathogenic bacteria were isolated from 87 patients with secondary infection of herpes zoster, of which 64 were Gram-negative bacteria (76.2B), 17 Gram-positive bacteria (20.2B), 3 fungi (3.6B), and Klebsiella pneumoniae (Klebsiella pneumoniae) against gentamicin and amikacin. The resistance rates of meropenem to gentamicin, amikacin and meropenem were 85.7% and 80.9%, respectively. The resistance rates of Pseudomonas aeruginosa to gentamicin, amikacin and meropenem were 66.7%, 83.3% and 88.9% respectively. The resistance rates of Escherichia coli to gentamicin, amikacin and meropenem were 60.093.93% and 100.0%, respectively, and those of Staphylococcus epidermidis to erythromycin. The drug resistance rates of Staphylococcus aureus to erythromycin, penicillin, vancomycin and vancomycin were 80.0 and 80.060.0.The coagulase-negative staphylococci were resistant to erythromycin and penicillin, respectively. The rates of vancomycin resistance were 80. 0% and 60. 0% respectively. Univariate analysis showed that herpes zoster secondary infection and age 鈮，

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