抗结核药致肝损害85例

发布时间：2018-05-08 03:41

本文选题：抗结核药 + 肝损害　；参考：《中国医院用药评价与分析》2016年12期

【摘要】：目的:探讨抗结核药致肝损害的危险因素及临床特点。方法:回顾性统计分析2014年1月—2015年5月在连云港市第四人民医院进行抗结核治疗患者的肝功能情况。结果:符合本调查标准的患者共1 333例,其中85例发生不同程度的肝损害,肝损害发生率为6.38%。其中,男性患者肝损害发生率为7.46%(59/791),女性为4.80%(26/542),两者的差异无统计学意义(P0.05);14~60岁患者肝损害发生率为5.56%(61/1 097),≥60岁患者为10.17%(24/236),两者的差异有统计学意义(P0.01)。85例发生肝损害患者中,61例(占71.76%)发生于用药60 d内;57例(占67.06%)出现典型肝炎临床症状,28例(占32.94%)无症状;经治疗,78例(占91.76%)患者痊愈或好转,7例(占8.24%)未愈。结论:抗结核药致肝损害发生率高,尤其是老年患者。因此,抗结核治疗时应注意预防药物性肝损害,密切监测,早期诊断,合理治疗。
[Abstract]:Objective: to investigate the risk factors and clinical features of liver injury caused by anti-tuberculosis drugs. Methods: the liver function of the patients treated with antituberculosis from January 2014 to May 2015 in Lianyungang fourth people's Hospital was analyzed retrospectively. Results: there were 1 333 patients who met the criteria of this survey, 85 of them had different degrees of liver damage, and the incidence of liver damage was 6.38%. Of which, The incidence of liver damage in male patients was 7.460.59 / 791g, and that in females was 4.800.26 / 542g. There was no significant difference between the two groups. The incidence rate of liver damage in patients aged 1460 years old was 5.560.61 / 1097% and 10.17 / 24 / 236in patients over 60 years of age, respectively. The difference between the two groups was statistically significant in 61 of 85 patients with liver damage. (71.76) 57 cases (67.06) had clinical symptoms of typical hepatitis within 60 days (32.94). 78 cases (91.76%) were cured or improved in 7 cases (8.24%). Conclusion: the incidence of liver damage caused by anti-tuberculosis drugs is high, especially in elderly patients. Therefore, prevention of drug-induced liver damage, close monitoring, early diagnosis and reasonable treatment should be paid attention to in anti-tuberculosis treatment.
【作者单位】：连云港市第四人民医院药学部;连云港市第四人民医院结核科;
【分类号】：R52;R575

【相似文献】