艾滋病患者肺孢子菌肺炎相关危险因素分析

发布时间：2018-05-08 04:02

本文选题：艾滋病 + 肺孢子菌肺炎　；参考：《中华医院感染学杂志》2015年22期

【摘要】：目的探讨艾滋病患者发生肺孢子菌肺炎(PCP)的危险因素,以期早期识别PCP的发生。方法选择2013年10月-2014年11月117例艾滋病患者为研究对象,采用回顾性研究的方法,分析艾滋病发生与未发生PCP患者年龄、性别、发现HIV感染至入院间隔时间、抗病毒治疗、口腔真菌病、淋巴细胞、CD3+T细胞、CD4+T细胞、CD8+T细胞、NK细胞计数等指标,应用SPSS 19.0软件进行统计分析。结果单因素分析结果为发现HIV感染至入院间隔时间、抗病毒、口腔真菌病以及淋巴细胞、CD3+T细胞、CD4+T细胞表达水平在发生与未发生PCP患者中差异有统计学意义(P0.05);多因素分析,CD4+T细胞以及发现HIV感染至入院间隔时间与PCP发生有关(P0.05);抗病毒、口腔真菌病以及淋巴细胞、CD3+T细胞计数为混杂因素(P0.05)。结论在HIV感染进入艾滋病期患者中,CD4+T细胞≤31.7个/μl、发现HIV感染至入院间隔平均时间≤3.5个月是预测PCP发生的较好指标。
[Abstract]:Objective to investigate the risk factors of pneumocystis pneumocystis pneumonia (PCPs) in AIDS patients and to identify the occurrence of PCPs early. Methods 117 AIDS patients from October 2013 to November 2014 were selected as the study subjects. The age and sex of the patients with PCP were analyzed by retrospective study. The time between HIV infection and admission was found, and the antiviral therapy was performed. The count of NK cells in CD 4 T cells and CD 8 T cells in patients with oral mycosis, CD 3 T cells and CD 8 T cells were analyzed by SPSS 19.0 software. Results the results of univariate analysis were as follows: the time between HIV infection and admission was found, and the antiviral effect was observed. The expression of CD 4 T cells in patients with oral mycosis and lymphocytic CD3 T cells was significantly different from that in patients with or without PCP. Multivariate analysis of CD4 T cells and the discovery of HIV infection to the interval between admission and hospitalization was associated with the development of PCP. The count of CD3 T cells in oral mycosis and lymphocytes was a mixed factor (P 0.05). Conclusion in the patients with HIV infection, the number of CD4 T cells is less than 31.7 / 渭 l, and the average interval between HIV infection and admission to hospital is less than 3.5 months, which is a good index to predict the occurrence of PCP.
【作者单位】：南通市第三人民医院感染科;
【基金】：江苏省预防医学科研基金资助项目(Y2012076) 南通市社会事业创新与示范计划基金资助项目(HS2014084) 南通市卫生局青年基金资助项目(WQ2014035)
【分类号】：R512.91

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