2009-2014年南通市结核分枝杆菌的耐药流行状况分析

发布时间：2018-05-09 02:30

本文选题：结核分枝杆菌 + 耐药结核病　；参考：《现代预防医学》2017年02期

【摘要】：目的了解近5年来南通市结核病的耐药状况,为制定切合该市结核病防控措施提供参考依据。方法对2009年10月1日-2014年6月30日该市培养阳性的1 893株分枝杆菌菌株运用比例法进行6种药敏试验(异烟肼、利福平、乙胺丁醇、链霉素、氧氟沙星和卡那霉素),计算耐药率。结果南通市结核分枝杆菌的总耐药率、单耐药率、多耐药率、耐多药率分别为21.34%、5.86%、3.17%、12.31%;复治患者总耐药率高于初治(P0.01);男性患者总耐药率和多耐药率高于女性(P0.01);40~59岁中年组总耐药率、耐多药率高于其他年龄组(P0.01)。结论该市耐多药结核病疫情防控形势不容乐观,应提高初治患者治愈率,积极推广应用快速诊断新技术。通过对耐药结核病患者的早发现、早诊断、早治疗,并提供心理支持、健康教育等环节,减少获得性耐药和原发性耐药的发生。
[Abstract]:Objective to investigate the drug resistance status of tuberculosis in Nantong City in recent 5 years and to provide reference basis for the establishment of tuberculosis prevention and control measures in Nantong City. Methods six drug susceptibility tests (isoniazid, rifampicin, ethambutanol, streptomycin) were carried out on 1 893 strains of Mycobacterium in the city from October 1, 2009 to June 30, 2014. Ofloxacin and kanamycin were calculated for drug resistance. Results the total drug resistance rate, single drug resistance rate, multidrug resistance rate and multidrug resistance rate of Mycobacterium tuberculosis in Nantong City were 21.34 and 5.86 respectively. The total drug resistance rate of patients with recurrent treatment was higher than that of P0.01A, and the total drug resistance rate of male patients was higher than that of female patients aged 4059 years. The rate of multidrug resistance was higher than that of other age groups (P 0.01). Conclusion the situation of prevention and control of MDR-TB in this city is not optimistic, the cure rate should be improved and the new technique of rapid diagnosis should be popularized. In order to reduce the occurrence of acquired drug resistance and primary drug resistance, early detection, early diagnosis, early treatment, psychological support, health education and so on were used to reduce the incidence of acquired drug resistance and primary drug resistance in patients with drug-resistant tuberculosis.
【作者单位】：南通市疾病预防控制中心;
【基金】：南通市社会发事业科技创新与示范项目(编号:HS149001) 第七轮中国全球基金结核病项目(CHN-708-G11-T)
【分类号】：R52

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