成都地区献血者HIV流行率、新感染发生率和窗口期输血残余风险评估

发布时间：2018-05-09 08:08

本文选题：人类免疫缺陷病毒 + 流行率　；参考：《中国输血杂志》2015年09期

【摘要】：目的分析成都地区献血者HIV流行率,新感染发生率,以及核酸检测系统引入前后窗口期输血残余风险。方法统计2011-2012年献血者资料,以确认抗-HIV阳性献血者数量计算HIV流行率,以重复献血者发生阳性转化的数量,和所有重复献血者的献血时间间隔总和计算HIV新感染发生率,并由此计算输血残余风险。结果在2年间的277 029名献血者中,抗-HIV流行率为0.061%。本中心在引入核酸检测系统前后,HIV窗口期输血残余风险分别是1/52 274和1/76 046。结论虽然将核酸检测系统引入血液筛查可以降低输血残余风险,但该风险仍然存在。提高输血安全性需要进一步加强献血者筛查力度,提高检测灵敏度,并尽量减少输血等措施。
[Abstract]:Objective to analyze the prevalence of HIV, the incidence of new infection, and the residual risk of blood transfusion before and after the introduction of nucleic acid detection system in Chengdu area. Methods the data of blood donors from 2011 to 2012 were analyzed in order to confirm the number of anti-HIV positive blood donors to calculate the prevalence rate of HIV, to calculate the incidence of new infection of HIV by the amount of positive transformation in repeat donors and the sum of blood donation intervals of all repeated blood donors. The residual risk of blood transfusion was calculated. Results the prevalence rate of anti-HIV was 0.061 among 277,029 blood donors in 2 years. Before and after the introduction of the nucleic acid detection system, the residual risk of HIV transfusion in the window was 1 / 52,274 and 1 / 76,046, respectively. Conclusion although the introduction of nucleic acid detection system into blood screening can reduce the residual risk of blood transfusion, the risk still exists. To improve the safety of blood transfusion, it is necessary to further strengthen the screening of blood donors, improve the sensitivity of detection, and reduce blood transfusion as far as possible.
【作者单位】：成都市血液中心;
【基金】：四川省卫生厅科研课题(编号120501)
【分类号】：R446.6;R512.91

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