干扰素联合普瑞巴林治疗带状疱疹后遗神经痛效果观察

发布时间：2018-05-10 06:32

本文选题：带状疱疹后遗症 + 神经痛　；参考：《山东医药》2017年26期

【摘要】：目的观察干扰素联合普瑞巴林治疗带状疱疹后遗神经痛(PHN)的疗效,以及对患者血清炎性因子水平的影响。方法将98例PHN患者随机分为观察组和对照组各49例,两组在常规对症治疗的基础上口服普瑞巴林,观察组另予重组人干扰素α-2b肌注,10 d为一疗程。比较两组的疗效,评价治疗第3、5、10、30天疼痛情况,检测治疗前后血清炎性因子IL-6、IL-10水平。结果观察组总有效率为89.8%,高于对照组的69.4%(P0.05);治疗第3、5、10、30天,观察组VAS均低于对照组(P均0.05);两组治疗后较治疗前血清IL-6水平降低、IL-10水平升高,且观察组IL-6低于对照组,IL-10高于对照组(P均0.05)。结论干扰素联合普瑞巴林治疗PHN能够促进炎性因子平衡,从而减轻患者疼痛程度、提高临床疗效。
[Abstract]:Objective to observe the therapeutic effect of interferon combined with Premarin in the treatment of postherpetic neuralgia (PHN) and the effect of interferon on the level of serum inflammatory factors. Methods Ninety-eight patients with PHN were randomly divided into two groups: the observation group (n = 49) and the control group (n = 49). The patients in the observation group were treated with recombinant human interferon 伪 -2b intramuscularly for 10 days as a course of treatment. To compare the curative effect of the two groups, to evaluate the pain at the 3rd day of treatment and to detect the level of IL-6 and IL-10 in serum before and after treatment. Results the total effective rate of the observation group was 89.8, which was higher than that of the control group (69.4%, P 0.05), the VAS of the observation group was lower than that of the control group (P 0.05) on the 30th day of treatment, the level of serum IL-6 decreased and the level of IL-10 increased after treatment. The IL-6 of the observation group was lower than that of the control group, and the level of IL-10 was higher than that of the control group (P < 0.05). Conclusion Interferon combined with Premarin can promote the balance of inflammatory factors, alleviate the pain and improve the clinical efficacy.
【作者单位】：青岛市海慈医疗集团;
【分类号】：R752.12

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