对CHB和HBV相关性肝硬化患者进行外周血Th17细胞频率检测的临床意义分析

发布时间：2018-05-13 06:42

本文选题：乙型肝炎病毒 + 慢性乙型肝炎　；参考：《当代医药论丛》2016年22期

【摘要】：目的 :分析对CHB和HBV相关性肝硬化患者进行外周血Th17细胞频率检测的临床意义。方法 :将近年来我院收治的60例CHB患者和HBV相关性肝硬化患者根据病情的不同分为CHB组(n=30)及HBV相关性肝硬化组(n=30),将同期在我院进行体检的30名健康人纳入正常组。对各组受试者进行外周血Th17细胞频率、血浆IL-17等指标的检测,然后对比分析其检测结果。结果 :与CHB组患者相比,HBV相关性肝硬化组患者的外周血Th17细胞频率及血浆IL-17的水平均较高,差异有统计学意义(P0.05)。与正常组受试者相比,CHB组患者的外周血Th17细胞频率及血浆IL-17的水平较高,差异有统计学意义(P0.05)。与HBV相关性肝硬化组患者相比,CHB组患者ALT的水平、HBV DNA的载量较高,其TBIL的水平较低,差异有统计学意义(P0.05)。两组患者ALT的水平、TBIL的水平均高于正常组受试者,差异有统计学意义(P0.05)。各组受试者的外周血Th17细胞频率与IL-17的水平呈正相关(P0.05)。结论 :随着CHB及HBV相关性肝硬化患者肝损伤程度的加重,其外周血中Th17细胞的频率可显著增高。Th17细胞诱导的IL-17分泌增多可能是导致肝损伤发生发展的主要原因。
[Abstract]:Objective: to analyze the clinical significance of detecting the frequency of peripheral blood Th17 cells in patients with CHB and HBV associated cirrhosis. Methods: sixty patients with CHB and patients with HBV associated cirrhosis were divided into CHB group (CHB group) and HBV associated cirrhosis group (30 cases) according to their condition. 30 healthy persons who were examined in our hospital were included in the normal group. The frequency of peripheral blood Th17 cells and plasma IL-17 were measured, and the results were compared. Results: compared with CHB group, the frequency of Th17 cells and the level of plasma IL-17 in patients with HBV-associated cirrhosis were higher than those in patients with HBV-associated cirrhosis, and the difference was statistically significant (P 0.05). The frequency of Th17 cells in peripheral blood and the level of plasma IL-17 in CHB group were higher than those in control group, and the difference was statistically significant (P 0.05). Compared with the patients with HBV associated cirrhosis, the levels of ALT and TBIL in patients with HBV were higher than those in patients with HBV associated cirrhosis, and the difference was statistically significant (P 0.05). The levels of ALT and TBIL in the two groups were higher than those in the normal subjects (P 0.05). There was a positive correlation between the frequency of Th17 cells and the level of IL-17 in each group (P 0.05). Conclusion: with the severity of liver injury in patients with CHB and HBV related cirrhosis, the frequency of Th17 cells in peripheral blood can be significantly increased. The increase of IL-17 secretion induced by Th17 cells may be the main cause of liver injury.
【作者单位】：常州市武进人民医院消化内科;
【分类号】：R512.62;R575.2

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