乙肝母婴阻断中婴幼儿隐匿性HBV感染研究

发布时间：2018-05-18 02:15

本文选题：阻断 + 母婴传播　；参考：《广东医学》2015年11期

【摘要】：目的研究乙肝母婴阻断中婴幼儿隐匿性感染情况和影响因素。方法通过深圳市疫苗监测和接种网络,收集223对乙肝母婴阻断人群的血清样本,进行HBV血清学和分子生物学检测,分析隐匿性感染对传统HBV母婴阻断效果评价标准的影响;并分析母婴阻断中婴幼儿隐匿性感染的因素。结果血清学结果显示223例婴幼儿接受乙肝母婴阻断后,212例HBb Ag(+),传统血清学结果计算HBV母婴阻断成功率为95.1%(212/223);分子生物学筛查显示,183例HBV-DNA(-),40例HBV-DNA(+),该方法计算HBV母婴阻断成功率为82.1%(183/223),两者差异有统计学意义(P0.05)。孕产妇血清HBV-DNA水平与所产婴幼儿隐匿性感染相关性分析显示,孕产妇血清HBV-DNA水平与婴幼儿隐匿性感染呈正相关;31例隐匿性感染的婴幼儿中有12例病毒S区"a"抗原决定簇出现点突变;而6例血清型HBs Ag(+)的病例S区"a"抗原决定簇没有发生突变,病毒突变对血清学漏检差异有统计学意义(χ2=7.025,P=0.020)。结论隐匿性感染在HBV母婴阻断婴幼儿群体中存在一定的流行趋势,并对HBV母婴阻断成功构成了威胁;病毒突变和孕产妇血清HBV-DNA水平与婴幼儿隐匿性感染呈正相关。
[Abstract]:Objective to study the occult infection and its influencing factors in infants with hepatitis B mother and child block. Methods Serum samples were collected from women with hepatitis B by vaccine surveillance and inoculation network in Shenzhen to detect HBV serology and molecular biology, and to analyze the influence of occult infection on the traditional criteria for evaluating the effect of maternal and infant block of hepatitis B virus (HBV). The factors of occult infantile infection in mother and child block were analyzed. Results the results of serology showed that 212 cases of HBb were treated with hepatitis B mother and child block, the success rate of maternal and infant block of HBV calculated by traditional serology was 95.112 / 223g, and the molecular biological screening showed that there were 183 cases of HBV-DNA and 40 cases of HBV-DNA. This method was used to calculate HBV for mother and child. The successful rate of blocking was 82.1% / 223%, and the difference was statistically significant (P 0.05). The correlation analysis between the serum HBV-DNA level of pregnant women and the latent infection in infants and infants was analyzed. There was a positive correlation between serum HBV-DNA level in pregnant and parturient women and occult infection in infants. Among 31 infants with occult infection, there were 12 cases of point mutation in the "a" antigen determinant of virus S region. However, there was no mutation in the "a" antigen determinant of S region in 6 patients with serotype HBs Ag(), and there was a significant difference in the serological failure of the virus mutation (蠂 ~ 2 = 7.025) (蠂 ~ (2) = 7.025) (蠂 ~ (2) = 7.025) (P < 0.020). Conclusion there is a certain epidemic trend of occult infection in infants with HBV blocking mother and child, and it is a threat to the success of maternal and infant block of HBV, and the mutation of virus and the level of serum HBV-DNA in pregnant and parturient women are positively correlated with the occult infection in infants and children.
【作者单位】：广东省深圳市人民医院龙华分院检验科;广东省深圳市光明新区疾病预防控制中心检验科;
【基金】：广东省深圳市卫生计生系统科研项目(编号:201402019)
【分类号】：R512.62;R446.6

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