乙肝相关性肝癌患者根治性切除术预后影响因素Cox回归分析

发布时间：2018-05-19 10:11

本文选题：乙肝相关性肝癌患者 + 根治性切除术　；参考：《中国公共卫生》2017年11期

【摘要】：目的了解乙肝相关性肝癌患者行根治性切除术后预后的影响因素,为提高肝癌术后患者的生存质量提供参考依据。方法对2003年12月—2012年12月在南京军区福州总医院行根治性肝切除术的426例乙肝相关性肝癌患者每2~4个月进行1次电话随访,了解其预后情况;应用R 3.1.2统计软件采用单因素和多因素Cox回归分析方法分析乙肝相关性肝癌患者行根治性切除术后预后的影响因素。结果随访的426例乙肝相关性肝癌患者术后的平均生存时间为(42.06±26.7)个月,其中第1、2、3、4、5年的生存率分别为86.15%、73.71%、66.67%、61.27%、58.92%;多因素Cox回归分析结果显示,肿瘤有血液转移、肝功能Child-Pugh分级B级、甲胎蛋白(AFP)含量400 ng/m L、Topo IIα高表达和饮酒是影响行根治性切除术后乙肝相关性肝癌患者预后的危险因素;有肿瘤包膜和Edmonson病理分级I级是影响行根治性切除术后乙肝相关性肝癌患者预后的保护因素。结论肿瘤包膜情况、血液转移情况、Edmonson病理分级、肝功能Child-Pugh分级、AFP含量、Topo IIα表达和饮酒情况是影响行根治性切除术后乙肝相关性肝癌患者预后的主要因素。
[Abstract]:Objective to investigate the prognostic factors of patients with Hepatitis B associated liver cancer after radical resection, and to provide a reference for improving the quality of life of patients with liver cancer. Methods from December 2003 to December 2012, 426 patients with Hepatitis B related liver cancer who underwent radical hepatectomy in Fuzhou General Hospital of Nanjing military region were followed up by telephone every 2 ~ 4 months. Using R3.1.2 statistical software, univariate and multivariate Cox regression analysis was used to analyze the prognostic factors of patients with Hepatitis B associated liver cancer after radical resection. Results the mean survival time was 42.06 卤26.7months after operation in 426 patients with Hepatitis B associated liver cancer, of which the survival rate of the 1st second trimester was 86.15 and the 5-year survival rate was 86.15. 73.71and 61.27g / 58.92.The multivariate Cox regression analysis showed that the tumor had blood metastasis and liver function Child-Pugh grade B, and the survival rate was 58.92.The results of multivariate Cox regression analysis showed that the tumor had blood metastasis and liver function Child-Pugh grade B, and the survival rate was 86.15%. The high expression of Topo II 伪 and alcohol consumption were the risk factors for the prognosis of Hepatitis B associated liver cancer patients after radical resection. Tumor capsule and Edmonson grade I were the protective factors for the prognosis of patients with Hepatitis B associated liver cancer after radical resection. Conclusion tumor capsule, blood metastasis, liver function Child-Pugh grade and the expression of Topo II 伪 and alcohol consumption are the main factors influencing the prognosis of patients with Hepatitis B associated liver cancer after radical resection.
【作者单位】：中山大学公共卫生学院;南京军区福州总医院肝胆外科;中山大学中山医学院;深圳市宝安区疾病预防控制中心;
【基金】：福建省自然科学基金重点项目(2014Y0034) 福州总医院创新团队专项资助项目(cxtd05)
【分类号】：R512.62;R735.7

【相似文献】