无干眼症状儿童过敏性结膜炎中的泪膜稳定性研究

发布时间：2018-05-19 21:23

本文选题：儿童过敏性结膜炎 + 干眼　；参考：《眼科》2015年04期

【摘要】：目的观察无干眼症状的儿童过敏性结膜炎患者的泪膜稳定性。设计回顾性病例系列。研究对象无干眼症状的儿童季节性过敏性结膜炎患者30例(60眼)。无干眼症状的屈光不正患儿20例(40眼)为正常对照组。方法受试者进行病史询问以及外眼、眼前节及干眼相关检查,包括泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)、角膜荧光素染色(FL)。荧光素染色评分0~12分,无染色为0分。主要指标BUT、SIt和FL评分。结果观察组与对照组BUT分别为(7.35±2.46)s、(11.95±2.183)s(t=9.569,P=0.000);SIt分别为(18.28±5.123)mm、(16.50±5.149)mm(t=1.702,P=0.092);FL评分不为0者分别为13例(20眼)、6例(6眼)(χ2=4.193,P=0.041)。观察组中FL评分、BUT与病史长短无显著相关性。结论无干眼症状的儿童季节性过敏性结膜炎患者也可能存在泪膜稳定性下降和角膜上皮完整性受损的改变。
[Abstract]:Objective to observe the stability of tear film in children with allergic conjunctivitis without xerophthalmia. Design retrospective case series. Participants 30 children with seasonal allergic conjunctivitis without xerophthalmia were treated with 60 eyes. 20 cases of ametropia without xerophthalmia (40 eyes) were used as control group. Methods the subjects were examined with medical history, external eye, anterior segment and dry eye, including tear film rupture time, basic tear secretion test and corneal fluorescein staining. The staining score of fluorescein was 0 ~ 12, and that of no staining was 0. Main outcome measures Butt it and FL scores. Results the BUT of the observation group and the control group were 11.95 卤2.183s ~ (9.569p) ~ (0.000) ~ (?) it was 18.28 卤5.123mm ~ (?) ~ 16.50 卤5.149m ~ (-1) ~ (702) ~ (0.092FL) respectively in 13 cases (n = 13) with a score of 0.092FL (蠂 ~ (24) 193P ~ (= 0.041), and that in the control group (n = 6) was not equal to that in the control group (P < 0.05). The BUT of the observation group and the control group was 11.95 卤2.183g / L respectively (蠂 ~ (24) 193P ~ (+). In the observation group, there was no significant correlation between FL score and history. Conclusion Children with seasonal allergic conjunctivitis without xerophthalmia may also have decreased tear film stability and impaired corneal epithelial integrity.
【作者单位】：首都医科大学附属北京儿童医院眼科;
【分类号】：R777.31

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