流行性感冒防治药物研究进展

发布时间：2018-05-26 05:03

本文选题：流行性感冒 + 药物　；参考：《国际药学研究杂志》2017年03期

【摘要】：目前药物防治仍是控制流感的主要措施之一。现有的流感防治药物主要包括M2离子通道阻滞剂和神经氨酸酶抑制剂,临床上虽有一定治疗作用,但其耐药性也日益突显。近年来,随着晶体学、病毒学及其他相关学科在制药领域的深入应用,不少新药已进入临床(前)试验,并取得了良好的抗病毒效果。其中最具代表性的包括广谱抗流感病毒血凝素抗体和病毒RNA聚合酶复合物小分子抑制剂。本文以流感病毒被用于靶标进行药物设计的几种重要蛋白为主线,分别介绍了近年来出现的一些具有较好应用前景的流感防治药物,以期为流感疫情防控提供参考。
[Abstract]:At present, drug control is still one of the main measures to control influenza. The existing influenza drugs mainly include M2 ion channel blockers and neuraminidase inhibitors. In recent years, with the further application of crystallography, virology and other related disciplines in pharmaceutical field, many new drugs have been used in clinical (pre-clinical) trials, and good antiviral effects have been achieved. The most representative of these include broad-spectrum anti-influenza virus hemagglutinin antibodies and small molecular inhibitors of viral RNA polymerase complexes. Based on several important proteins of influenza virus used for drug design, this paper introduces some influenza prevention and control drugs which have good application prospect in recent years, in order to provide reference for the prevention and control of influenza epidemic situation.
【作者单位】：广西医科大学基础医学院;解放军疾病预防控制所传染病预防控制中心;军委联合参谋部警卫局保健处;
【基金】：国家重点研发计划(2016YFC1200905) 国家高技术研究发展计划(863计划)(2014AA020516) 国家自然科学基金资助项目(81371807,20873999)
【分类号】：R511.7

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