艾滋病科学数据资源调查和主题数据库框架设计

发布时间：2018-05-26 14:12

本文选题：艾滋病 + 科学数据　；参考：《中国疾病预防控制中心》2013年硕士论文

【摘要】：研究目的了解我国艾滋病相关的科学数据资源(艾滋病相关业务数据、科技成果、基金项目以及科学文献)的现状,构建艾滋病主题数据库框架。研究方法本研究采用间接调查的方法对1983年至2011年的艾滋病相关的科学数据资源(包括业务数据、科技成果、基金项目以及科技文献等)进行检索,利用文献计量分析法和信息资源规划法对数据资源进行规划和分类,在此基础上设计艾滋病主题数据库框架,为人口与健康科学数据管理和共享工程资源组织者的艾滋病信息采集工作提供指导。研究结果 1.共查找到艾滋病相关的业务数据库6个,并检索到艾滋病相关科技成果1050项(1988年—2010年)、中文科技文献66939项(1983年—2011年)、英文科技文献10389项(1983年—2011年)、科研基金项目357项(1999年—2011年)。 2.各个数据库资源文献计量分析主要结果如下：(1)艾滋病相关业务数据库主要由中国疾病预防控制中心性病艾滋病中心管理,内容集中在高危人群感染率的监测、高危行为干预、美沙酮维持治疗以及抗病毒治疗情况等方面。(2)艾滋病领域相关科技成果主要集中在2000年至2010年,共992项,占94.4%；获得科技成果最多的单位为高等院校,共407项(39%)；科技成果完成人的合作网络呈小规模聚集状；艾滋病相关科技成果集中在以下领域：艾滋病基础研究集中在诊断试剂盒的研制、基因工程疫苗、免疫佐剂、抗体等方面；艾滋病临床方面,包括基因诊断、药物、鉴别诊断及结核病、性病等共感染疾病的研究；艾滋病的预防和控制,包括女性、大学生、吸毒人群等高危人群的流行病学研究、艾滋病的防治、干预模式如行为干预、健康教育等方面研究；艾滋病药学方面,集中在基因工程药、抗病毒药、抗病毒药的生产制作工艺、产业化、合成以及剂型的研究方面；中医中药方面,包括中药有效成分的提取、药物的合成等。(3)艾滋病领域基金项目信息共357项,其中1999年到2011年12年间艾滋病领域共获国家自然科学基金333项；2001年—2011年间获国家重大基础研究计划资助11项,十五、十一五国家科技支撑计划13项。国家自然科学基金对艾滋病领域的资助力度不断加大,资助格局突出基础医学,资助领域集中在艾滋病病毒变异、免疫机制、艾滋病毒疫苗研究等方面。(4)艾滋病领域相关的科技文献数量从1983年到2011年呈逐年上升趋势。中国疾病预防控制中心发表的中文科技文献最多,且与各地区的疾病预防控制中心合作最显著。我国科研机构与美国合作最多,其次为澳大利亚、瑞士、日本和印度。聚类分析结果显示,科技文献内容囊括了艾滋病基础、临床、预防控制、药学和中医中药学等各方面。艾滋病基础研究领域主要包括艾滋病病毒的生活周期、基因结构、致病机理、艾滋病病毒疫苗等；临床研究主要包括艾滋病合并感染的性病、结核、肿瘤以及机会性感染等疾病及其临床特点、诊断、治疗、不良反应、护理、临床分析等方面；预防与公共卫生研究包括艾滋病的干预、评价、监测、调查、督导与评估、检测与咨询、实验室管理、报告等方面；艾滋病药学研究体现在抗病毒药物设计、药物研发、药物选择、药物滥用、耐药性等方面；而中医中药学研究包括中药配方、中药药理、中药长期干预、中药疗效以及中医治疗等方面。 3.基于文献计量分析中关键词共词聚类分析结果、突变词监测分析结果以及基金项目、科研成果、文献综述、网站和书籍目录,对艾滋病领域资源进行规划,并建立包括基础研究、临床研究、预防与公共卫生研究、药学研究和中医中药学研究5个一级目录,艾滋病病毒的生活周期、基因结构、致病机理、艾滋病病毒疫苗、艾滋病合并感染的性病、结核、肿瘤以及机会性感染等疾病及其临床特点、诊断、治疗、不良反应、护理、临床分析、艾滋病的干预、评价、监测、调查、督导与评估、检测与咨询、实验室管理、报告、抗病毒药物设计、药物研发、药物选择、药物滥用、耐药性、中药配方、中药药理、中药长期干预、中药疗效以及中医治疗38个二级目录,以及病毒基因结果及主要功能研究、艾滋干预策略、抗原抗体检测、HIV-1膜融合抑制剂及中草药治疗等147个三级目录的艾滋病主题数据库框架。研究结论 1.中国疾病预防控制中心性病艾滋病中心集中掌握艾滋病领域的业务数据。 2.科技成果、基金数据和科技文献计量分析数据显示我国艾滋病领域信息量大,信息持有者众多,研究内容包括在基础医学、临床医学、预防与公共卫生学、药学和中医中药学等方面。 3.艾滋病主题数据库框架的设计是以艾滋病领域的业务活动为导向,采用信息资源规划法和文献综述法,构建包括基础医学、临床医学、预防与公共卫生学、药学和中医中药学在内的共5个一级、38个二级、147个三级目录的主题数据库框架。但仍需请包括艾滋病基础医学、临床医学、预防控制与公共卫生学、药学和中医中药学领域专家对框架进一步评估,并与资源拥有者联系,尝试对框架进行资源填充,并在此基础上对框架进一步修改,使目前已有的艾滋病相关资源物尽其用。
[Abstract]:Purpose of study

To understand the current situation of AIDS - related scientific data resources ( AIDS - related business data , science and technology achievements , fund projects and scientific literature ) , and construct the framework of AIDS theme database .

Research Methods

This research adopts indirect survey method to search AIDS - related scientific data resources ( including business data , science and technology achievements , fund projects and scientific literature , etc . ) from 1983 to 2011 . The data resources are planned and classified by means of literature measurement analysis method and information resource planning method . Based on this , the framework of AIDS theme database is designed to provide guidance for AIDS information collection work of population and health science data management and shared engineering resource organizers .

Results of the study

1 . There are 6 business databases related to AIDS and 1,050 scientific and technological achievements related to AIDS ( 1988 - 2010 ) , 66939 in Chinese scientific and technological documents ( 1983 - 2011 ) , 10389 of English scientific and technical documents ( 1983 - 2011 ) , 357 ( 1999 - 2011 ) .

2 . The main results are as follows : ( 1 ) AIDS - related business database is mainly managed by the STD / AIDS Center of China Centers for Disease Control and Prevention , the content is concentrated in the surveillance of the infection rate of high - risk population , the intervention of high - risk behaviors , the maintenance and treatment of Methandione and the treatment of antiviral therapy .
There are 407 ( 39 % ) of the highest scientific and technological achievements in institutions of higher learning ;
The cooperative network of the achievement of the scientific and technological achievements is in a small - scale aggregate form ;
AIDS - related scientific and technological achievements are concentrated in the following areas : AIDS basic research focuses on the development of diagnostic kits , genetic engineering vaccines , immune adjuvants , antibodies and the like ;
The clinical aspects of AIDS include gene diagnosis , medicine , differential diagnosis , tuberculosis and sexually transmitted diseases .
The prevention and control of AIDS , including the epidemiology of high - risk groups such as female , college students , drug users , prevention and control of AIDS , intervention mode , such as behavioral intervention and health education ;
The pharmaceutical aspects of AIDS are concentrated on the research aspects of the production and manufacturing technology , industrialization , synthesis and dosage forms of gene engineering drugs , antiviral drugs and antiviral drugs ;
China ' s traditional Chinese medicine , including the extraction of effective components of Chinese medicine , the synthesis of drugs , etc . ( 3 ) There are 357 projects in the field of AIDS , including 333 from 1999 to 12 years of AIDS in the field of AIDS ;
The number of scientific and technological documents related to AIDS has increased steadily from 1983 to 2011 . The results of the cluster analysis show that the content of science and technology documents in China is the largest in the fields of AIDS virus variation , immune mechanism , HIV vaccine research , etc . The research field of AIDS is mainly composed of AIDS virus , clinical , preventive control , pharmacy and Chinese medicine . The research field of AIDS is mainly including life cycle , gene structure , pathogenesis , HIV vaccine and so on .
The clinical research mainly includes the diseases , clinical characteristics , diagnosis , treatment , adverse reaction , nursing , clinical analysis and so on of STD , tuberculosis , tumor and opportunistic infection .
Prevention and public health research includes intervention , evaluation , monitoring , investigation , supervision and evaluation , detection and consultation , laboratory management , reporting and other aspects of AIDS ;
The pharmaceutical research of AIDS is embodied in the aspects of antiviral drug design , drug R & D , drug selection , drug abuse , drug resistance , etc .
Traditional Chinese medicine studies include traditional Chinese medicine formula , traditional Chinese medicine pharmacology , long - term Chinese medicine intervention , traditional Chinese medicine curative effect and traditional Chinese medicine treatment .

3 . Based on the results of the cluster analysis , the results of the analysis of the mutation words , the research achievements , the literature review , the website and the book catalogue , the resources in the field of AIDS have been planned and established , including basic research , clinical research , prevention and public health , AIDS virus vaccine , HIV infection , disease , tuberculosis , tumor , opportunistic infection , etc . and its clinical characteristics , diagnosis , treatment , adverse reaction , nursing , clinical analysis , AIDS intervention , evaluation , monitoring , investigation , drug abuse , drug resistance , drug R & D , drug selection , drug abuse , drug resistance , drug R & D , drug selection , drug abuse , drug resistance , drug R & D , drug selection , drug abuse , drug resistance , drug R & D , drug selection , drug abuse , drug resistance , HIV - 1 membrane fusion inhibitor and Chinese herbal medicine treatment .

Conclusions of the study

1 . The Center for STD / AIDS in the Center for Disease Prevention and Control of China has concentrated on the business data in the field of AIDS .

2 . The data of scientific and technological achievements , fund data and scientific and technological documents show that the amount of AIDS in China is large and the information holder is numerous . The research contents include the aspects of basic medicine , clinical medicine , prevention and public health , pharmacy and traditional Chinese medicine .

3 . The framework of AIDS theme database is designed based on the operational activities in the field of AIDS . It uses the information resource planning method and the literature review method to construct the theme database framework including the basic medicine , clinical medicine , prevention and public health , pharmacy and traditional Chinese medicine . However , the framework is further evaluated by experts including the basic medicine of AIDS , clinical medicine , prevention and control and public health , pharmacy and traditional Chinese medicine .
【学位授予单位】：中国疾病预防控制中心
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R512.91

【参考文献】