血流感染的危险因素分析及其与早期炎症因子相关性研究

发布时间：2018-05-29 09:47

本文选题：血流感染 + 炎症因子　；参考：《中国现代医学杂志》2015年11期

【摘要】：目的分析血流感染(BSI)流行病学的独立危险因素并探究炎症因子TNF-α、IL-6、IL-1β、IL-8与BSI早期的关系,为BSI的预防和临床诊疗提供参考依据。方法采用临床病例对照研究方法,用ELISA法测定BSI患者早期血清TNF-α、IL-6、IL-1β、IL-8水平,并采用SPSS软件和多因素Logistic回归分析模型分析BSI与侵袭性治疗、合并严重基础疾病以及患者年龄、性别、住院天数、免疫力的关系。结果患者进行侵袭性治疗,合并严重基础疾病,以及年龄、住院天数、免疫力均是BSI的危险因素。进行侵袭性治疗及合并严重基础疾病的患者发生BSI的几率更大(P0.01);患者的年龄越大,住院时间越长,免疫力越低,发生BSI的几率越大(P0.05);而性别与BSI无相关性(P0.05)。与正常对照组比较,炎症因子TNF-α、IL-6、IL-1β和IL-8水平在BSI早期明显提高(P0.05)。结论侵袭性治疗、合并严重基础疾病以及患者年龄大、住院时间长、免疫力低均是BSI流行病学的危险因素,为BSI的预防提供重要的参考依据;炎症因子TNF-α、IL-6、IL-1β和IL-8在BSI早期起重要作用,可作为BSI早期诊疗的参考依据。
[Abstract]:Objective to analyze the independent risk factors of blood flow infection (BSI) epidemiology and to explore the relationship between the inflammatory factor TNF- 伪, IL-6, IL-1 尾, IL-8 and the early stage of BSI, so as to provide reference for the prevention and clinical diagnosis and treatment of BSI. Methods the early serum levels of TNF- 伪, IL-6, IL-1 尾 and IL-8 in patients with BSI were measured by ELISA method. SPSS software and multivariate Logistic regression model were used to analyze the relationship between BSI and invasive therapy, severe underlying diseases, age and sex of the patients. The relationship between days of hospitalization and immunity. Results aggressive treatment, severe basic diseases, age, length of stay and immunity were all risk factors of BSI. The patients with aggressive therapy and severe basic diseases were more likely to develop BSI, and the older the patients were, the longer they were in hospital, the lower their immunity was, and the higher the incidence of BSI was, the higher the incidence of BSI was. There was no correlation between sex and BSI (P0.05). Compared with the normal control group, the levels of IL-1 尾 and IL-8 in the inflammatory factor TNF- 伪 and IL-6 were significantly increased in the early stage of BSI (P 0.05). Conclusion aggressive treatment, severe basic diseases, age, long hospital stay and low immunity are the risk factors of BSI epidemiology, which provide important reference for the prevention of BSI. The inflammatory cytokines TNF- 伪, IL-6, IL-1 尾 and IL-8 play an important role in the early stage of BSI, and can be used as a reference for early diagnosis and treatment of BSI.
【作者单位】：中国康复研究中心(北京博爱医院)感染科;
【分类号】：R51

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