FibroTouch与FIB-4对慢性乙型肝炎肝纤维化的诊断价值

发布时间：2018-05-29 10:05

  本文选题：FibroTouch + FIB-　； 参考：《广东医学》2017年18期

【摘要】：目的比较瞬时弹性成像技术Fibro Touch与FIB-4对慢性乙型肝炎肝纤维化的诊断价值。方法收集肝脏病理符合慢性乙型肝炎的患者共计110例,Fibro Touch测量肝脏硬度值(LSM),同时完善FIB-4数值。结果 LSM数值与肝组织炎症及纤维化分期呈正相关(r分别是0.532,0.670;均P0.001)。LSM数值在HBV DNA(copies/m L)10~3、10~3~10~5、10~5 3组间差异有统计学意义[(11.03±4.39)k Pa、(14.57±5.17)k Pa、(22.45±10.68)k Pa,P0.05]。FIB-4及Fibro Touch预测严重肝纤维化的AUROC分别为0.789(95%CI 0.711~0.854,P0.001)及0.866(95%CI 0.788~0.924,P0.001);预测早期肝硬化的AUROC分别为0.778(95%CI0.689~0.852,P0.001)及0.830(95%CI 0.746~0.895,P0.001)。结论 LSM数值与HBV DNA水平,肝脏炎症及纤维化程度呈正相关,Fibro Touch及FIB-4对于慢乙肝严重肝纤维化及肝硬化均具有良好的预测价值,Fibro Touch优于FIB-4。
[Abstract]:Objective to compare the diagnostic value of transient elastic imaging (Fibro Touch) and FIB-4 in chronic hepatitis B liver fibrosis. Methods A total of 110 patients with chronic hepatitis B whose liver pathology was in accord with chronic hepatitis B were collected to measure the liver hardness and improve the FIB-4 value. Results there was a positive correlation between LSM value and hepatic inflammation and fibrosis stage (r = 0.532n0.670, respectively), and there was a significant difference in P0.001).LSM value between HBV DNA(copies/m group and HBV DNA(copies/m group (11.03 卤4.39k Patius 14.57 卤5.17k Pao 22.45 卤10.68k P0. 05). FIB-4 and Fibro Touch in predicting severe hepatic fibrosis were 0.789(95%CI 0.7110.854mP0.001, respectively. The AUROC of early cirrhosis was 0.778T95 (CI 0.6890.852mP0.001) and 0.830(95%CI 0.7460.895g / P0.001g respectively. Conclusion the value of LSM is positively correlated with the level of HBV DNA, the degree of inflammation and fibrosis of liver. Fibro Touch and FIB-4 are good predictors of severe hepatic fibrosis and cirrhosis of chronic hepatitis B. Fibro Touch is superior to FIB-4.
【作者单位】： 广西中医药大学附属瑞康医院肝病科;
【基金】：国家自然科学基金资助项目(编号:81473532) 广西八桂学者建设工程专项经费资助
【分类号】：R512.62;R575.2
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本文编号：1950469