酒精性肝硬化和乙型肝炎肝硬化患者的凝血功能比较研究

发布时间：2018-05-30 20:38

本文选题：肝硬化 + 肝炎　；参考：《中国全科医学》2017年S1期

【摘要】：目的比较酒精性肝硬化和乙型肝炎肝硬化患者的凝血功能。方法选取2015年1月—2016年12月信阳市中心医院收治的肝硬化患者120例,根据疾病类型分为酒精性肝硬化组(n=36)和乙型肝炎肝硬化组(n=84);另选取同期无凝血功能障碍的胃病患者118例,为对照组。比较3组患者的凝血功能指标,包括凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、国际标准化比值(INR)、凝血酶时间(TT)、纤维蛋白原(FIB)。结果 3组患者PT、APTT、INR、TT、FIB比较,差异有统计学意义(P0.05)。Child-Pugh分级为A、B级患者中,酒精性肝硬化组患者PT、APTT短于乙型肝炎肝硬化组患者,INR低于乙型肝炎肝硬化组患者,FIB高于乙型肝炎肝硬化组患者,差异有统计学意义(P0.05);两组患者TT比较,差异无统计学意义(P0.05)。Child-Pugh分级为C级患者中,酒精性肝硬化组患者FIB高于乙型肝炎肝硬化组患者(P0.05);两组患者PT、APTT、INR、TT比较,差异无统计学意义(P0.05)。结论酒精性肝硬化患者和乙型肝炎肝硬化患者的凝血功能存在差异,当以凝血功能评价患者的肝功能时,应考虑两者间的差异。
[Abstract]:Objective to compare the coagulation function between alcoholic cirrhosis and hepatitis B cirrhosis. Methods 120 patients with liver cirrhosis admitted in Xinyang Central Hospital from January 2015 to December 2016 were divided into alcoholic cirrhosis group (n = 36) and hepatitis B cirrhosis group (n = 84). Control group. The indexes of coagulation function, including prothrombin time (PTT), activated partial thromboplastin time (APTTT), international standard ratio (INR), thrombin time (TT), fibrinogen (FIBN), were compared among the three groups. Results there was a significant difference among the three groups of patients with P0.05N. Child-Pugh grade of Agna B, compared with the three groups of patients with PTT APTTT / INRV FIB, and there was a significant difference among the three groups. In alcoholic cirrhosis group, PTT APTT was shorter than that in hepatitis B cirrhosis group and FIB was higher in alcoholic cirrhosis group than that in hepatitis B cirrhosis group, the difference was statistically significant (P 0.05). The FIB of alcoholic cirrhosis group was higher than that of hepatitis B cirrhosis group (P 0.05), but there was no significant difference between two groups (P 0.05). Conclusion there are differences in coagulation function between patients with alcoholic cirrhosis and patients with hepatitis B cirrhosis, and the difference between them should be considered when evaluating the liver function of patients with alcoholic cirrhosis and hepatitis B cirrhosis.
【作者单位】：河南省信阳市中心医院;
【分类号】：R512.62;R575.2

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