中国西南地区结核分枝杆菌临床分离菌株一线药物耐药状况调查

发布时间：2018-06-02 18:17

本文选题：结核分枝杆菌 + 耐药性　；参考：《中国人兽共患病学报》2017年04期

【摘要】：目的了解西南地区结核分枝杆菌临床分离株的耐药表型及其影响因素情况,为结核病的预防和控制提供基础参考数据。方法选取中国西南4个地区(贵州、广西、四川和重庆)2006—2013年从结核病患者痰标本中分离培养的500株结核分枝杆菌,用比例法药物敏感试验对4种一线抗结核药物进行药物敏感性检测,用SPSS22.0中的χ~2检验和Logistic回归进行统计学分析。结果 500株结核分枝杆菌临床分离株,对INH、RFP、EMB和SM的耐药率分别为30.40%、26.00%、9.80%和24.40%,总体耐药率和耐多药率分别是40.60%和27.20%;贵州、四川、广西和重庆的总耐药率和MDR率分别为64.10%和46.15%、59.54%和51.90%、28.88%和14.97%、20.19%和3.85%。χ~2检验结果显示,各地区间菌株对4种药物的耐药率、总体耐药率和耐多药率差异均有统计学意义(P0.05);多因素Logistic回归分析结果显示,地区和病例类型是结核病耐药及耐多药发生的影响因素(P0.05)。结论西南地区,特别是贵州和四川的耐药结核病、尤其是耐多药结核病的流行状况严峻。应加强结核分枝杆菌耐药性监测,以指导临床用药和预防控制耐药结核病的发生和流行。
[Abstract]:Objective to understand the drug resistance phenotype and its influencing factors of Mycobacterium tuberculosis clinical isolates in Southwest China, and to provide basic reference data for the prevention and control of tuberculosis. Methods 500 tuberculosis branches were isolated and cultured from sputum specimens from patients with tuberculosis from 2006 to 2013 in 4 Southwest China (Guizhou, Guangxi, Sichuan and Chongqing). The drug sensitivity test of 4 kinds of first-line anti tuberculosis drugs was carried out by the proportion method of drug sensitivity test. The statistical analysis was carried out by the chi square ~2 test and Logistic regression in SPSS22.0. Results the resistance rates of 500 Mycobacterium tuberculosis clinical isolates to INH, RFP, EMB and SM were 30.40%, 26%, 9.80% and 24.40% respectively, and the overall resistance rate and multidrug resistance. The rates of total resistance and MDR in Guizhou, Sichuan, Guangxi and Chongqing were 64.10% and 46.15%, 59.54% and 51.90%, 28.88% and 14.97%, 20.19% and 3.85%. Chi ~2 test results showed that the resistance rate of the strains to 4 drugs, the overall resistance rate and the multidrug resistance rate were statistically significant (P0.05) and multifactor Logis. Tic regression analysis shows that regional and case types are the factors affecting drug resistance and multidrug resistance (P0.05). Conclusion the prevalence of drug-resistant tuberculosis in the southwest, especially in Guizhou and Sichuan, especially MDR - TB, is severe. Drug resistance monitoring should be strengthened to guide clinical medication and preventive control. The occurrence and prevalence of drug-resistant tuberculosis.
【作者单位】：南华大学公共卫生学院;中南大学湘雅医学院生理学系;中国疾病预防控制中心传染病预防控制所/传染病预防控制国家重点实验室/传染病诊治协同创新中心;
【基金】：国家科技重大专项(No.2013ZX10003002-001)资助~~
【分类号】：R446.5;R52

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