血小板源性生长因子B及受体α mRNA在复发性尖锐湿疣皮损中的表达与意义

发布时间：2018-06-03 00:34

本文选题：尖锐湿疣 + 生长因子　；参考：《重庆医学》2017年13期

【摘要】：目的研究血小板源性生长因子B(PDGF-B)及其受体α(PDGFR-α)mRNA在复发性尖锐湿疣皮损中的表达及意义。方法采用实时荧光定量聚合酶链反应检测复发性、未复发性尖锐湿疣皮损和正常皮肤中PDGF-B及PDGFR-αmRNA表达水平。结果尖锐湿疣复发组、未复发组的PDGF-B和PDGFR-αmRNA表达水平均明显高于对照组,差异有统计学意义(P0.05);复发组PDGF-B和PDGFR-αmRNA表达水平高于未复发组,复发组治疗前PDGF-B和PDGFR-αmRNA水平高于治疗后(P0.01)。结论 PDGF-B和PDGFR-αmRNA可能与尖锐湿疣的复发有一定的关系。
[Abstract]:Objective to study the expression and significance of platelet-derived growth factor (PDGF-B) and its receptor 伪 -PDGFR- 伪 in recurrent condyloma acuminatum. Methods the expression levels of PDGF-B and PDGFR- 伪 mRNA in recurrent and non-recurrent condyloma acuminatum skin lesions and normal skin were detected by real-time fluorescence quantitative polymerase chain reaction. Results the expression levels of PDGF-B and PDGFR- 伪 mRNA in recurrent condyloma acuminatum group and non-recurrence group were significantly higher than those in control group (P 0.05), the expression levels of PDGF-B and PDGFR- 伪 mRNA in recurrent group were higher than those in non-recurrence group, and the levels of PDGF-B and PDGFR- 伪 mRNA in recurrent group were higher than those in post-treatment group (P 0.01). Conclusion PDGF-B and PDGFR- 伪 mRNA may be related to the recurrence of condyloma acuminatum.
【作者单位】：皖南医学院弋矶山医院皮肤性病科;
【基金】：2013年度高校省级自然科学研究项目(KJ2013B324)
【分类号】：R752.53

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