西安市结核分枝杆菌耐药基线调查

发布时间：2018-06-04 00:32

本文选题：结核分枝杆菌 + 肺结核　；参考：《中国感染控制杂志》2016年12期

【摘要】：目的了解西安市肺结核患者的耐药疫情及初始耐药与获得性耐药的耐药情况,为耐药结核病的治疗以及控制模式提供依据。方法将2015年西安市14个区(县)结核病门诊和西安市胸科医院所有初治及复治痰结核分枝杆菌培养阳性的病例作为研究对象,进行4种一线抗结核药物的敏感性试验。结果西安市结核分枝杆菌总耐药率为31.9%,耐多药(MDR)率为7.0%。初治组耐药率为27.3%,MDR率为3.5%。复治组耐药率为59.5%,MDR率为28.6%,复治组耐药率与MDR率均明显高于初治组,差异均有统计学意义(均P0.001)。结论西安市肺结核患者总耐药率低于全国平均水平,但MDR率略高于全国水平,说明西安市结核病防控工作虽然取得一定成效,但形势依然严峻,特别是要加强初治患者的管理以减少耐药结核病的发生。
[Abstract]:Objective to investigate the situation of drug resistance and initial and acquired drug resistance in tuberculosis patients in Xi'an, and to provide evidence for the treatment and control mode of drug resistant tuberculosis. Methods four first-line anti-tuberculosis drugs were tested in 14 districts (counties) of Xi'an city in 2015 and all the cases with positive culture of Mycobacterium tuberculosis in phlegm treated and retreated in Xi'an chest Hospital in 2015. Results the total drug resistance rate of Mycobacterium tuberculosis in Xi'an was 31. 9%, and the MDR rate of multi-drug resistance was 7. 0%. The drug resistance rate of the first treatment group was 27.3% and the MDR rate was 3.5%. The drug resistance rate of the treated group was 59.5% and the MDR rate of the treated group was 28.6.The drug resistance rate and the MDR rate in the treatment group were significantly higher than those in the initial treatment group (all P 0.001). Conclusion the total drug resistance rate of tuberculosis patients in Xi'an is lower than the national average, but the rate of MDR is slightly higher than that of the whole country, which indicates that although the tuberculosis prevention and control work in Xi'an has achieved certain results, the situation is still grim. In particular, the management of newly treated patients should be strengthened to reduce the incidence of drug-resistant tuberculosis.
【作者单位】：西安市疾病预防控制中心;
【基金】：西安市科技局项目[SF1208(5)]
【分类号】：R52

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