普通干扰素联合利巴韦林治疗1b型丙肝患者疗效分析

发布时间：2018-06-05 09:30

  本文选题：丙型肝炎 + 干扰素　； 参考：《东南大学学报(医学版)》2017年06期

【摘要】：目的:探讨应用普通干扰素联合利巴韦林治疗基因1b型慢性丙型肝炎疗效。方法:自2013年3月至2016年11月入组158例基因1b型慢性丙型肝炎患者,应用普通干扰素联合利巴韦林抗病毒治疗48周并随访24周,分别于治疗第12周、24周和48周,随访第24周检测HCV RNA和肝功能,监测疗效。结果:1.在158例入组的基因1b型慢性丙型肝炎患者治疗过程中因严重不良反应停药10例,包括8例出现白细胞重度下降,2例出现精神烦躁。完成疗程及随访患者共148例。2.148例完成研究的慢性丙型肝炎患者治疗过程中监测HCV RNA和肝功能发现,治疗后第12周、24周、48周及随访第24周HCV RNA转阴率分别为71.0%、84.5%、90.5%、71.6%,肝功能ALT复常率分别为87.2%、90.5%、92.6%、85.1%。结论:普通干扰素联合利巴韦林治疗1b型慢性丙型肝炎患者48周病毒学及生化学应答率高,但停药后复发率亦高。普通干扰素联合利巴韦林治疗仍可作为1b型慢性丙型肝炎的有效治疗手段。
[Abstract]:Objective: to investigate the efficacy of interferon combined with ribavirin in the treatment of chronic hepatitis C with gene 1 b. Methods: from March 2013 to November 2016, 158 patients with chronic hepatitis C type 1b were treated with interferon and ribavirin for 48 weeks and followed up for 24 weeks. HCV RNA and liver function were measured at the 24th week of follow-up, and the curative effect was monitored. The result is 1: 1. During the treatment of 158 patients with chronic hepatitis C type 1b gene, 10 patients were stopped because of serious adverse reactions, including 8 patients with severe leukocytopenia and 2 patients with mental irritability. HCV RNA and liver function were monitored in 148 patients with chronic hepatitis C who completed the course of treatment and followed up. After 12 weeks, 24 weeks, 48 weeks and 24 weeks of follow-up, the rate of HCV RNA turning negative was 71.0 and 84.5%, 90.5% and 71.6, respectively. The recovery rate of liver function ALT was 87.2%, 90.5% and 92.6%, respectively. Conclusion: the virological and biochemical response rates of patients with chronic hepatitis C 1 b treated with interferon combined with ribavirin in 48 weeks were high, but the recurrence rate was also high after withdrawal. Interferon combined with ribavirin can still be used as an effective therapy for chronic hepatitis C 1 b.
【作者单位】： 江苏大学附属句容市人民医院传染科;东南大学附属第二医院传染病研究所;
【基金】：江苏省卫生厅基金资助项目(YG201508) 江苏大学科技支撑项目(JLY20140076)
【分类号】：R512.63
，

本文编号：1981510