贵州雷山苗族HBV血清学标志物与ALT检测分析

发布时间：2018-06-05 13:16

本文选题：乙型肝炎病毒 + 丙氨酸氨基转移酶　；参考：《现代预防医学》2015年16期

【摘要】：目的了解雷山苗族人群中的乙肝病毒(HBV)感染情况与血清丙氨酸氨基转移酶(ALT)的异常率。方法对734名苗族体检者应用酶联免疫吸附法(ELISA)测定血清学标志物(HBVM),用速率法检测ALT。结果乙肝病毒表面抗原(HBs Ag)阳性率为5.86%,乙肝病毒e抗原(HBe Ag)阳性率为1.50%,ALT异常率为10.08%。HBs Ag阳性的感染模式只出现"大三阳"和"小三阳"两种。不同年龄段间,HBs Ag阳性率、HBe Ag阳性率和HBVM五项全阴性率,以及ALT异常率差异有统计学意义。乙肝病毒表面抗体(抗-HBs)阳性率随性别的差异以及随年龄的差异均有统计学意义;此外,对于不同感染模式间,ALT异常差异有统计学意义。结论雷山地区苗族HBs Ag阳性率和ALT异常率均较低,但HBVM五项全阴性率达49.73%,提示本地区应继续加强乙肝免疫接种,做好肝病防治工作。
[Abstract]:Objective to investigate the prevalence of hepatitis B virus (HBV) infection and the abnormal rate of serum alanine aminotransferase (alt) in Leishan Miao population. Methods 734 healthy people of Miao nationality were tested for serum HBV MN by Elisa and alt by rate method. Results the positive rate of hepatitis B virus surface antigen (HBs) was 5.86, and the positive rate of hepatitis B virus e antigen (HBe) was 1.50. The positive rate of alt was 10.08%.HBs Ag positive. There were only "Big three positive" and "small three positive". The positive rate of HBs Ag and the total negative rate of five items of HBVM, as well as the abnormal rate of ALT were significantly different among different age groups. The positive rate of anti-HBsAg was significantly different with sex and age, in addition, there were significant differences in alt abnormality among different infection modes. Conclusion the positive rate of HBs Ag and the abnormal rate of ALT in the Miao nationality in Leishan area are lower, but the total negative rate of five items of HBVM is 49.73, which suggests that the immunization of hepatitis B should continue to be strengthened and the prevention and treatment of liver disease should be done well in this area.
【作者单位】：贵州省贵阳医学院分子生物学重点实验室;
【基金】：国家科技支撑计划(2013BAI05B03):贵州世居少数民族常见疾病早期诊断与干预研究
【分类号】：R512.62

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