H6N1亚型禽流感病毒跨种属传播研究进展

发布时间：2018-06-06 10:41

本文选题：甲型流感病毒 + HN亚型　；参考：《中国人兽共患病学报》2017年03期

【摘要】：禽流感病毒H6N1亚型广泛存在于水禽和陆禽,是最常分离到的甲型流感病毒亚型,遗传分析表明该病毒可能是高致病禽流感病毒H5N1的前体。随着病毒基因的持续进化,H6N1可跨种间屏障传播至哺乳动物,其对于哺乳动物小鼠、猪和雪貂已经具有较强感染能力。血清流行病学调查结果显示少数人H6禽流感病毒抗体阳性,2013年5月,我国台湾出现全球首例人类感染H6N1亚型流感病毒。因此,H6N1病毒宿主范围不断扩大,在这些宿主内可发生病毒基因突变、基因重配,进而演变为具有感染人类潜能的新变异株的可能。本文从病原学、流行病学、病毒感染哺乳动物和人类等方面对H6N1亚型禽流感病毒的研究进展进行综述,以期为H6N1禽流感病毒的防控提供参考。
[Abstract]:H6N1 subtype of avian influenza virus exists widely in waterfowl and land bird. It is the most commonly isolated influenza A virus subtype. Genetic analysis indicates that this virus may be the precursor of highly pathogenic avian influenza virus H5N1. With the continuous evolution of the virus gene, H6N1 can be transmitted to mammals across the interspecific barrier. It has a strong ability to infect mammalian mice, pigs and ferrets. Seroepidemiological investigation showed that a few people were positive for H6 avian influenza virus. In May 2013, the first human infection with H6N1 subtype influenza virus appeared in Taiwan. Therefore, the host range of H6N1 virus is expanding, and the mutation and reassortment of the virus gene can occur in these hosts, which may lead to the possibility of a new variant strain with the potential to infect human beings. This paper reviews the research progress of H6N1 subtype avian influenza virus from the aspects of etiology, epidemiology, virus infection in mammals and humans, in order to provide reference for the prevention and control of H6N1 avian influenza virus.
【作者单位】：广西医科大学微生物学教研室;广西医科大学基础医学院;
【基金】：国家自然科学基金项目(Nos.31260033&31660041) 广西自然科学基金项目(No.2013GXNSFAA019118)联合资助~~
【分类号】：R511.7

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