伏立康唑首次成功治疗难治性面部Majocchi肉芽肿1例并文献复习

发布时间：2018-06-06 10:50

  本文选题：Majocchi肉芽肿 + 红色毛癣菌　； 参考：《中国真菌学杂志》2016年05期

【摘要】：目的首次报道伏立康唑成功治疗1例红色毛癣菌引起的顽固性面部Majocchi肉芽肿,分析患者的临床表现、病理特点、真菌学检查及分子生物学鉴定结果,并总结英文报道病例。方法患者男,50岁,因面部浸润性红斑溃疡5a就诊,取患处皮损进行组织病理学检查、真菌学检查、药物敏感试验及PCR检测。结果诊断:红色毛癣菌致面部Majocchi肉芽肿。治疗:伏立康唑静脉治疗2周改伏立康唑片剂口服,治疗4个月后患者原有皮损基本消退,真菌学阴性,无不良反应。结论 Majocchi肉芽肿临床罕见,复杂难治,疗程长,易反复,严重影响患者生活质量,我们首次应用伏立康唑成功治疗顽固性Majocchi肉芽肿,为临床治疗难治性Majocchi肉芽肿提供新的诊疗经验。
[Abstract]:Objective to report for the first time the successful treatment of a case of refractory facial Majocchi granuloma caused by Trichophyton rubrum. Methods the patient, aged 50 years, was treated for 5 years because of facial infiltrating erythema ulcer. Histopathological examination, mycological examination, drug sensitivity test and PCR test were performed. Results: Majocchi granuloma of face was caused by Trichophyton rubrum. Treatment: Volconazole tablets were given orally for 2 weeks. After 4 months of treatment, the original skin lesions were basically disappeared, mycology was negative, and no adverse reactions were found. Conclusion Majocchi granuloma is rare in clinical practice, complex and difficult to be treated. The course of treatment is long and easy to repeat, which seriously affects the quality of life of the patients. We successfully treated refractory Majocchi granuloma with Volconazole for the first time. To provide new experience for clinical treatment of refractory Majocchi granuloma.
【作者单位】： 南京军区南京总医院皮肤科;中国医学科学院皮肤病医院;
【分类号】：R756.6
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本文编号：1986272