中老年人类免疫缺陷病毒感染者抗反转录病毒治疗后的代谢变化

发布时间：2018-06-13 03:20

本文选题：人类免疫缺陷病毒 + 抗反转录病毒治疗　；参考：《中国感染与化疗杂志》2015年06期

【摘要】：目的评估抗反转录病毒治疗(ART)对中老年人类免疫缺陷病毒(HIV)感染者代谢的影响及变化特点。方法随机选择51例接受ART的40岁以上HIV感染者,监测治疗1年后患者的体质量指数、血压、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白等常用代谢及相关指标变化,分析其原因及应对措施。结果 51例中老年HIV感染者接受ART后1年,患者上述检测指标都有不同程度的变化,主要表现为高三酰甘油、高胆固醇、高低密度脂蛋白及低高密度脂蛋白血症等脂代谢紊乱,部分患者出现糖代谢异常及高血压。其中,以三酰甘油、低密度脂蛋白异常变化较为常见。导致代谢紊乱的疾病谱中,单一指标异常14例(27.4%),代谢综合征5例(9.8%),混合型高脂血症4例(7.8%),2项及以上指标异常但未达到代谢综合征诊断标准者19例(37.2%)。以上变化统计显示差异有统计学意义(P0.05)。结论中老年HIV感染者接受ART后,受药物、社会、心理和生活方式等多种因素的影响,代谢紊乱的发生率明显增加。
[Abstract]:Objective to evaluate the effects and characteristics of antiretrovirus therapy (ART) on metabolism of HIV infected persons. Methods 51 patients over 40 years old with art were randomly selected. Body mass index (BMI), blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein (HDL) were monitored after one year of treatment. The changes of low density lipoprotein and other common metabolism and related indexes were analyzed, and the causes and countermeasures were analyzed. Results after one year of art, 51 cases of HIV infected with HIV had varying degrees of changes, including hypertriglyceride, high cholesterol, high and low density lipoprotein, low density lipoprotein and low density lipoproteinemia. Some patients had abnormal glucose metabolism and hypertension. Among them, triacylglycerol, low density lipoprotein abnormal changes are more common. In the spectrum of diseases leading to metabolic disorder, there were 14 cases with abnormal single index, 5 cases with metabolic syndrome with 9. 8% and 7. 8% with mixed hyperlipidemia, 19 cases with abnormal and above indexes but not up to the diagnostic standard of metabolic syndrome in 19 cases (37. 2%). The statistical difference was statistically significant (P 0.05). Conclusion after receiving art, the incidence of metabolic disorder increased significantly in the middle-aged and elderly HIV infected persons, influenced by many factors, such as drug, social, psychological and lifestyle.
【作者单位】：福建医科大学附属闽东医院感染性疾病科;第四军医大学唐都医院全军感染病诊疗中心;
【基金】：福建中医药大学2014年临床专项课题(X132014099)
【分类号】：R512.91

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