败血症患者感染病原菌检测与耐药性分析

发布时间：2018-06-24 22:29

本文选题：败血症 + 病原菌　；参考：《中华医院感染学杂志》2015年04期

【摘要】：目的研究败血症患者感染病原菌检测及耐药性分析,为临床治疗提供参考数据。方法对2012年3月-2013年3月135例确诊为败血症患者采集血培养标本,采用BACTEC 9050型全自动血液培养仪进行培养,用outuneims型细菌鉴定及药敏分析系统进行病原菌鉴定以及药敏试验分析,数据采用SPSS13.0统计软件进行处理。结果 135例患者血标本共检出98株病原菌,检出率为72.59%;其中革兰阴性菌66株占67.35%、革兰阳性菌17株占17.35%及真菌15株占15.30%;革兰阴性菌对氟喹诺酮类药物耐药率相对较高,对氨苄西林、环丙沙星及磺胺甲VA唑/甲氧苄啶耐药率分别为90.91%、87.88%、87.88%;革兰阳性菌对于多种抗菌药物亦呈现出较高耐药率,而对万古霉素敏感性最高,达88.24%。结论加强对败血症患者感染病原菌的检测十分必要,以降低耐药菌株的扩散。
[Abstract]:Objective to study the pathogenic bacteria detection and drug resistance analysis of septicemia patients, and to provide reference data for clinical treatment. Methods 135 cases of septicemia in March 2012 -2013 were collected from blood culture specimens, BACTEC 9050 full-automatic blood culture apparatus was used for culture, and outuneims type bacteria identification and drug sensitivity analysis system were used for disease. SPSS13.0 statistical software was used for the analysis of original bacteria identification and drug sensitivity test. The results showed that 98 strains of pathogenic bacteria were detected in 135 cases, of which 66 were Gram-negative bacteria, 67.35% were gram-negative, 17.35% Gram-positive and 15 of fungi were 15.30%, and the resistance rate of Gram-negative bacteria to fluoroquinolones was relatively high. The resistance rates of ampicillin, ciprofloxacin and sulfamethoxazole / trimethoprim were 90.91%, 87.88%, 87.88%, respectively. Gram-positive bacteria also showed high resistance to a variety of antibiotics, and the highest sensitivity to vancomycin. 88.24%. concluded that it was necessary to strengthen the detection of pathogenic bacteria in septicemia patients to reduce drug resistance. The spread of the plant.
【作者单位】：临沂市沂水中心医院检验科;浙江大学医学院附属第一医院消化内科;
【基金】：国家级自然科学基金资助项目(81070366)
【分类号】：R515.3

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