替诺福韦酯治疗多重耐药慢性乙型肝炎的回顾性分析

发布时间：2018-07-09 16:50

本文选题：替诺福韦酯 + 多重耐药　；参考：《中国药房》2015年23期

【摘要】：目的:观察替诺福韦酯(TDF)治疗多重耐药慢性乙型肝炎(CHB)的短期疗效及不良反应。方法:回顾性分析32例多重耐药CHB患者病历资料,所有患者治疗前均进行乙型肝炎病毒(HBV)耐药基因检测,存在多位点耐药,并给予TDF口服治疗。观察TDF治疗前、后丙氨酸氨基转移酶(ALT)复常率、HBV-DNA阴转率、乳酸、肾功能等指标。结果:治疗第3个月时,ALT复常率达100%,治疗半年时HBV-DNA阴转率达96.88%,治疗中患者未出现乳酸水平升高及肾功能异常。结论:TDF治疗多重耐药CHB疗效迅速,未出现明显不良反应。
[Abstract]:Aim: to observe the short-term efficacy and adverse reactions of tenofovir ester (TDF) in the treatment of multi-resistant chronic hepatitis B (CHB). Methods: the medical records of 32 patients with multidrug resistance CHB were retrospectively analyzed. All patients were tested for hepatitis B virus (HBV) resistance gene before treatment and TDF was given orally. Before and after TDF treatment, the recovery rate of alanine aminotransferase (alt) and HBV-DNA negative conversion rate, lactic acid, renal function and so on were observed. Results: the recovery rate of alt was 100 at the 3rd month of treatment, and the negative conversion rate of HBV-DNA was 96.88 at the end of six months. There was no increase in lactic acid level and abnormal renal function in the patients. Conclusion the effect of TDF on multi-drug resistant CHB is rapid and there is no obvious adverse reaction.
【作者单位】：天津市第二人民医院ICU;
【分类号】：R512.62

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