血清HBsAg水平对恩替卡韦治疗HBeAg阳性的慢性乙肝患者病毒学应答的影响

发布时间：2018-07-11 09:34

本文选题：肝炎 + 乙型　；参考：《山东医药》2015年13期

【摘要】：目的观察血清HBsAg水平对恩替卡韦治疗HBeAg阳性的慢性乙肝患者病毒学应答的影响。方法选择HBeAg阳性的慢性乙肝患者120例,所有患者行恩替卡韦治疗。根据患者治疗后是否合并病毒学应答将患者分为合并组77例及未合并组43例,收集两组治疗前及治疗后3、6个月血清HBsAg、HBeAg水平及HBVDNA载量。结果两组治疗前血清HBsAg、HBeAg及HBVDNA载量比较差异无统计学意义(P均0.05)。合并组治疗后3、6个月HBeAg、HBVDNA转阴率均明显高于未合并组(P均0.05)。治疗3个月后,两组血清HBsAg、HBeAg水平逐步下降,且合并组下降幅度显著高于未合并组(P均0.05)。治疗6个月后,两组血清HBsAg、HBeAg水平下降幅度接近,未合并组血清HBsAg、HBeAg水平高于合并组,但差异无统计学意义(P均0.05)。结论HBeAg阳性的慢性乙肝患者恩替卡韦治疗后HBsAg水平是衡量治疗效果的重要参数,治疗后HBsAg水平越低其病毒学应答越明显。
[Abstract]:Objective to observe the effect of serum HBsAg level on virological response of patients with HBeAg positive chronic hepatitis B treated with entecavir. Methods 120 patients with HBeAg positive chronic hepatitis B were treated with entecavir. According to the virological response, the patients were divided into the combined group (77 cases) and the uncombined group (43 cases). The serum HBsAg HBeAg levels and HBV DNA load were collected before treatment and 3,6 months after treatment. Results there was no significant difference in serum HBsAg HBeAg and HBV DNA load between the two groups before treatment (P 0.05). The negative rate of HBeAgN HBV DNA in the combined group was significantly higher than that in the uncombined group 3 and 6 months after treatment (all P 0.05). After 3 months of treatment, the serum HBsAg HBeAg level in the two groups gradually decreased, and the decrease in the combined group was significantly higher than that in the uncombined group (P 0.05). After 6 months of treatment, the level of serum HBsAg HBeAg in the two groups was similar to that in the uncombined group, but the level of HBeAg in the serum of the uncombined group was higher than that in the combined group, but the difference was not statistically significant (P 0.05). Conclusion the level of HBsAg in HBeAg-positive patients with chronic hepatitis B is an important parameter to evaluate the therapeutic effect after treatment with entecavir. The lower the level of HBsAg after treatment, the more obvious the virological response.
【作者单位】：青海省第五人民医院;
【基金】：青海省(应用)基础研究计划项目(2013-Z-739)
【分类号】：R512.62

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