γ干扰素及其诱导蛋白10在不同临床阶段慢性HBV感染老年患者中的表达

发布时间：2018-07-22 13:55

【摘要】：目的探讨γ干扰素及其诱导蛋白(IP)-10在不同临床阶段慢性乙肝病毒(HBV)感染老年患者中的表达情况。方法 160例该院诊断为慢性HBV感染的老年患者,根据疾病不同时期分为耐受组(免疫耐受期)、活动组(免疫活动期)及重型组(重型HBV)。空腹抽取静脉血检测相关生化指标及γ干扰素、IP-10水平。结果耐受组丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、总胆红素(TBil)、HBV-DNA均低于活动组与重型组(P0.05);活动组均低于重型组(P0.05)。耐受组γ干扰素及IP-10水平均低于活动组与重型组(P0.05);活动组均低于重型组(P0.05)。γ干扰素及IP-10与ALT、AST、TBil、HBV-DNA存在正相关关系(P0.05)。结论γ干扰素及IP-10通过免疫反应参与了慢性HBV感染的病理损伤过程,且与肝组织的损伤存在密切相关性,在探索性研究中可进一步深入以期寻找到更理想的治疗靶点。
[Abstract]:Objective to investigate the expression of interferon 纬 and its inducible protein (IP)-10 in elderly patients with chronic hepatitis B virus (HBV) infection in different clinical stages. Methods 160 elderly patients with chronic HBV infection were divided into tolerance group (immune tolerance stage), active group (immune active stage) and severe group (severe HBV) according to different stages of the disease. Fasting venous blood samples were taken to detect the biochemical indexes and the level of IP-10 of interferon-纬 (IFN- 纬). Results the levels of alt, AST, ALB, TBil in tolerance group were lower than those in active group and severe group (P0.05), while those in active group were lower than that in severe group (P0.05). The levels of interferon 纬 and IP-10 in tolerance group were lower than those in active group and severe group (P0.05), and the levels of IFN- 纬 and IP-10 in active group were lower than those in severe group (P0.05). Conclusion Interferon 纬 and IP-10 participate in the pathological damage process of chronic HBV infection through immunoreaction, and have close relationship with liver tissue damage, which can be further explored in order to find a more ideal therapeutic target.
【作者单位】：南阳医专高等专科学校第一附属医院;
【分类号】：R512.62

【参考文献】